The carcinoembryonic antigen- (CEA-) related cell adhesion molecules (CEACAMs) constitute a 12-member subgroup of the CEA family of immunoglobulin-related proteins first described in 1965 (PMID 4953873). CEACAMs are reported to participate in diverse physiological processes, including cell adhesion, differentiation, proliferation, and survival, as well as in carcinogenesis and bacterial pathogenesis. CEACAM molecules from neighbouring cells can interact via their respective extracellular N-terminal IgV-like domain and mediate cell-cell adhesion through trans-oligomerization. CEACAM molecules within the same cell can also undergo transmembrane domain-mediated cis-oligomerization, an event important for sustaining downstream cellular signaling. Athough CEACAM1 is shown to utilize its cytoplasmic domain for transducing cellular signaling, not all CEACAM members are expressed with a significant cytoplasmic domain, and others (CEACAM5/6/7/8) are GPI-anchored without even a transmembrane domain. (PMID 4735478). Human CEACAM5 (also known as CD66e, CEA, Ceacam5, Meconium antigen 100; UniProt P06731) is encoded by the CEACAM5 (or CEA) gene (NCBI Gene ID 1048). It is a GPI-anchored CEACAM with the most extracellular Ig domains, 7 in all.

Purified CEA from pooled tumors.

Detect Carcinoembryonic Antigen using this Anti-Carcinoembryonic Antigen Antibody, clone 1105 validated for use in ELISA, RIA.

Research Category
Apoptosis & Cancer

Research Sub Category
Tumor Markers

Sandwich RIA or EIA

Optimal working dilutions must be determined by the end user.

Human Carcinoembryonic Antigen (CEA)

Format: Purified

Purified immunoglobulin (Protein A). Liquid in PBS, pH 7.4 containing 0.1% sodium azide.

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store below -20°C or in dry ice as precipitation will occur.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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