MAB5264
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211
clone 8211, Chemicon®, from mouse
别名:
NGF-Receptor p75, Low Affinity NGF Receptor, NGFR
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
8211, monoclonal
Application:
immunocytochemistry
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
western blot
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
western blot
Species reactivity:
human
Citations:
10
Technique(s):
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211, clone 8211, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
8211, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NTF3(4908)
Application
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Reacts with NGF-receptors in human system.
General description
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
75 kDa
Immunogen
Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1111
Physical form
Format: Purified
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Darren Carwardine et al.
Journal of the neurological sciences, 367, 311-318 (2016-07-18)
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an
Daisuke Ito et al.
PloS one, 14(3), e0213252-e0213252 (2019-03-07)
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety trials
Gaetana Minnone et al.
RMD open, 3(2), e000441-e000441 (2017-09-29)
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue
Mary-Louise Rogers et al.
Journal of neuroimmunology, 226(1-2), 93-103 (2010-06-16)
The common neurotrophin receptor P75NTR, its co-receptor sortilin and ligand proNGF, have not previously been investigated in Natural Killer (NK) cell function. We found freshly isolated NK cells express sortilin but not significant amounts of P75NTR unless exposed to interleukin-12
Darren Carwardine et al.
PloS one, 12(12), e0188967-e0188967 (2017-12-12)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix
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