MABF121
抗-SV40 Large T Antigen抗体，克隆PAb416
clone PAb416, from mouse
别名:
Large T antigen, LT, LT-AG
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
PAb416, monoclonal
Application:
ICC, WB
Citations:
20
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
PAb416, monoclonal
species reactivity
SV40-infected cells
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
General description
猿猴病毒（SV40）大T和小T抗原均由SV40基因组的早期区域编码。大的T抗原结合DNA，并与53,000道尔顿的细胞蛋白p53形成复合物，p53是裂解生长过程中启动病毒DNA复制所必需的。此外，大T抗原与DNA聚合酶和转录因子AP-2结合，并与视网膜母细胞瘤易感基因的P105产物形成特异性复合物。
观测分子量〜82 kDa
Immunogen
纯化的SV40大T抗原
表位：SV40大T抗原
Application
免疫细胞化学分析：一个来自独立实验室的代表性批次在ICC中检测到SV40大T抗原（Sabatier，J.，et al.（2005）.58(4):429-431.; Del Valle, L., et al. (2004).J Virol.78（7）:3462-3469.）。
抗SV40大T抗原抗体，克隆PAb416是抗SV40大T抗原的抗体，用于蛋白质印迹、ICC。
研究子类别
免疫球蛋白 & 免疫学
免疫球蛋白 & 免疫学
研究类别
炎症 & 免疫学
炎症 & 免疫学
Biochem/physiol Actions
该抗体识别SV40的大T抗原。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
纯化蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
Analysis Note
对照
Cos-1细胞裂解物
Cos-1细胞裂解物
通过蛋白质印迹法在Cos-1细胞裂解物中进行评估。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg Cos-1细胞裂解物中检测到SV40大T抗原。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg Cos-1细胞裂解物中检测到SV40大T抗原。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Luis Del Valle et al.
Viruses, 12(11) (2020-11-07)
Progressive Multifocal Leukoencephalopathy (PML) is a fatal demyelinating disease of the CNS, resulting from the lytic infection of oligodendrocytes by the human neurotropic polyomavirus JC (JCPyV), typically associated with severe immunocompromised states and, in recent years, with the use of
Sonia Ramamoorthy et al.
Cancer, 117(11), 2379-2385 (2011-06-01)
Anal carcinoma is thought to be driven by human papillomavirus (HPV) infection through interrupting function of cell regulatory proteins such as p53 and pRb. John Cunningham virus (JCV) expresses a T-antigen that causes malignant transformation through development of aneuploidy and
Marie N Sorin et al.
Cell reports, 42(2), 112114-112114 (2023-02-16)
BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, and virus tropism. Infectious entry of
David Leuenberger et al.
Clinical and vaccine immunology : CVI, 14(8), 959-968 (2007-06-01)
Impaired BK virus (BKV)-specific immunity is a key risk factor of polyomavirus-associated nephropathy. We hypothesized that BKV agnoprotein might constitute an important immune target, as it is highly expressed after infection in vitro. We demonstrate abundant expression of BKV agnoprotein
Linda C Knight et al.
Journal of molecular biomarkers & diagnosis, 1(1) (2010-01-01)
A targeted nanoconjugate is being developed for non-invasive detection of gene expression in cells expressing the JC virus oncoprotein, T-antigen, which has been associated with medulloblastoma and other cancers. JC virus T-antigen localizes predominantly to the nucleus via a classical
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