MABN92-AF488
Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor™ 488 Conjugate
clone 20A12.1, from mouse, ALEXA FLUOR™ 488
别名:
Allograft inflammatory factor 1, AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.45
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
20A12.1, monoclonal
Application:
IHC
Citations:
1
biological source
mouse
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
purified antibody
antibody product type
primary antibodies
clone
20A12.1, monoclonal
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... AIF1(199)
General description
Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17 kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.
~17 kDa observed
Application
Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor™ 488 Conjugate is an antibody against Iba1/AIF1 for use in Immunohistochemistry.
Analysis Note
Evaluated by Immunohistochemistry in human spleen tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.
Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.
Other Notes
Concentration: Please refer to lot specific datasheet.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Hao-Cheng Chang et al.
The Journal of biological chemistry, 299(1), 102728-102728 (2022-11-22)
Haploinsufficiency in retinoic acid induced 1 (RAI1) causes Smith-Magenis syndrome (SMS), a severe neurodevelopmental disorder characterized by neurocognitive deficits and obesity. Currently, curative treatments for SMS do not exist. Here, we take a recombinant adeno-associated virus (rAAV)-clustered regularly interspaced short
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