MABT335
Anti-Desmoglein-3, clone 5G11 Antibody
clone 5G11, from mouse
别名:
Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6
产品名称
Anti-Desmoglein-3, clone 5G11 Antibody, clone 5G11, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5G11, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DSG3(1830)
Analysis Note
Evaluated by Immunohistochemistry in human tonsil and human skin tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Desmoglein-3 in human tonsil and human skin tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Desmoglein-3 in human tonsil and human skin tissue.
Application
Immunohistochemistry Analysis: A representative lot detected Isocitrate Desmoglein-3 in human scalp hair follicles and epidermal inclusions (Wu, H., et al. (2003). J Invest Dermatology. 120(6):1152-1157).
Immunohistochemistry Analysis: A representative lot detected Isocitrate Desmoglein-3 in in human adult skin tissue (Wu, H., et al. (2013). New England Journal of Med. 343(1):31-35).
Immunohistochemistry Analysis: A representative lot detected Isocitrate Desmoglein-3 in in human adult skin tissue (Wu, H., et al. (2013). New England Journal of Med. 343(1):31-35).
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
This Anti-Desmoglein-3, clone 5G11 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Desmoglein-3.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
107 kDa calculated
Desmoglein-3 (DSG3) is a calcium binding membrane protein that is localized desmosome cellular junctions and interacts with plaque proteins and intermediate filaments at cell-cell adhesion points. Desmosomes are cell-cell junctions between epithelial, myocardial and other cells types. Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament cytoskeleton. It is thought that raft membrane microdomains play a role in desmosome homeostasis by regulating the dynamics of desmosome assembly and disassembly. In human keratinocytes, Desmoglein-3 (DSG3) is raft associated and disruption of rafts prevents desmosome assembly. Desmoglein-3 is one of four sister proteins in the desmoglein family. Desmoglein-3 is also the autoantigen for Pemphigus vulgaris (PV) a lethal skin disease that is a result of autoantibodies against Desmoglein-3.
Immunogen
Recombinant protein corresponding to human Desmoglein-3.
Other Notes
Concentration: Please refer to lot specific datasheet.
Replaces: MABT470
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
10 - Combustible liquids
Hope E Burks et al.
The Journal of cell biology, 222(11) (2023-09-21)
Melanoma is an aggressive cancer typically arising from transformation of melanocytes residing in the basal layer of the epidermis, where they are in direct contact with surrounding keratinocytes. The role of keratinocytes in shaping the melanoma tumor microenvironment remains understudied.
Alejandra Valenzuela-Iglesias et al.
Molecular cancer research : MCR, 17(5), 1195-1206 (2019-01-19)
Loss of the desmosomal cell-cell adhesion molecule, Desmoglein 1 (Dsg1), has been reported as an indicator of poor prognosis in head and neck squamous cell carcinomas (HNSCC) overexpressing epidermal growth factor receptor (EGFR). It has been well established that EGFR
Marihan Hegazy et al.
Developmental cell, 57(24), 2683-2698 (2022-12-11)
Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are poorly understood. Here, we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, desmoglein-1 (Dsg1). Dsg1
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