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Merck
CN

PC246

Sigma-Aldrich

Anti-GluR1 Rabbit pAb

liquid, Calbiochem®

别名:

Anti-Glutamate Receptor I

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UNSPSC代码:
12352203
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生物来源

rabbit

质量水平

抗体产品类型

primary antibodies

克隆

polyclonal

表单

liquid

包含

≤0.1% sodium azide as preservative

种属反应性

rat

制造商/商品名称

Calbiochem®

储存条件

do not freeze

同位素/亚型

IgG

运输

wet ice

储存温度

2-8°C

一般描述

Anti-GluR1, rabbit polyclonal, recognizes the ~105-107 kDa GluR1 in D425 Med cells and hippocampal neurons. Also cross-reacts with a 50 kDa protein in rat brain. It is validated for WB and IF.
Purified rabbit polyclonal antibody. Recognizes the ~105-107 kDa GluR1 protein.
Recognizes the ~105-107 kDa GluR1 protein in D425 Med cells and hippocampal neurons. Also cross-reacts with a 50 kDa protein in rat brain extracts.

免疫原

a synthetic peptide (RTSDSRDHTRVDWKR) corresponding to amino acids 271-285 of rat GluR1 (numbered from the signal peptide)

应用

Immunoblotting 1-5 µg/ml)

Immunofluorescence (10-20 µg/ml, see application references)

包装

Please refer to vial label for lot-specific concentration.

分析说明

Positive Control
D425 Med cells, hippocampal neurons

其他说明

Also recognizes a smaller band at ~50 kDa using whole brain extracts. Immunofluorescence of dissociated cultured rat hippocampal neurons gave a punctate distribution, consistent with previous reports of GluR1 distribution. Antibody should be titrated for optimal results in individual systems.
Zuo, J. et al. 1997. Nature388, 769.
McHugh, T.J., et al. 1996. Cell87, 1339.
Tsien, J.Z., et al. 1996. Cell87, 1327.
Greenamyre, J.T. and Porter, R.H.P. 1994. Neurology44, S7.
Hollmann, M. and Heinemann, S. 1994. Ann. Rev. Neurosci.17, 31.
Bliss, T.V.P. and Collingridge, G.L. 1993. Nature361, 31.
Lomeli, H., et al. 1993. FEBS Lett.315, 318.
Molnar, E. et al. 1993. Neuroscience53, 307.
Advokat, C. and Pellegrin, A.I. 1992. Neurosci. Biobehav. Rev.16, 13.
Beal, M.F. 1992. FASEB J.6, 3338.
Rothman, S.M. 1992. Ann. NY Acad. Sci.648, 132.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

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储存分类代码

10-13 - German Storage Class 10 to 13

法规信息

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Dhrubajyoti Chowdhury et al.
Frontiers in synaptic neuroscience, 11, 6-6 (2019-03-28)
AMPA-type glutamate receptors (AMPARs) are clustered into functional nanodomains at postsynaptic sites through anchorage by the scaffolding protein, postsynaptic density protein-95 (PSD-95). The synaptic abundance of AMPARs is dynamically controlled in various forms of synaptic plasticity. Removal of AMPARs from
Jessica A Loweth et al.
The European journal of neuroscience, 50(3), 2590-2601 (2018-09-18)
In several brain regions, ongoing metabotropic glutamate receptor 1 (mGlu1) transmission has been shown to tonically suppress synaptic levels of Ca2+ -permeable AMPA receptors (CP-AMPARs) while pharmacological activation of mGlu1 removes CP-AMPARs from these synapses. Consistent with this, we previously
David S Tukey et al.
The Journal of biological chemistry, 288(49), 35297-35306 (2013-10-18)
Regulation of striatal medium spiny neuron synapses underlies forms of motivated behavior and pathological drug seeking. A primary mechanism for increasing synaptic strength is the trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) into the postsynapse, a process mediated by GluA1 AMPAR
Huong T T Ha et al.
Frontiers in molecular neuroscience, 11, 405-405 (2018-12-14)
During development, pyramidal neurons undergo dynamic regulation of AMPA receptor (AMPAR) subunit composition and density to help drive synaptic plasticity and maturation. These normal developmental changes in AMPARs are particularly vulnerable to risk factors for Autism Spectrum Disorders (ASDs), which
Michael Notaras et al.
Molecular psychiatry, 25(12), 3360-3379 (2019-10-23)
Synaptic plasticity requires a tight control of mRNA levels in dendrites. RNA translation and degradation pathways have been recently linked to neurodevelopmental and neuropsychiatric diseases, suggesting a role for RNA regulation in synaptic plasticity and cognition. While the local translation

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