生物来源
rabbit
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
包含
≤0.1% sodium azide as preservative
种属反应性
mouse, rat, human
制造商/商品名称
Calbiochem®
储存条件
do not freeze
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
一般描述
This product has been discontinued.
Recognizes the ~85 kDa hMre-11 protein in IMR90 and K562 cells.
Affinity purified rabbit polyclonal antibody. Recognizes the ~85 kDa hMre-11 protein.
Anti-hMre-11, rabbit polyclonal, recognizes the ~85 kDa hMre-11 protein in IMR90 and K562 cells. It is validated for use in Western blotting, immunofluorescence, and immunoprecipitation.
免疫原
Human
recombinant, human hMre11 protein
应用
Immunoblotting (1 g/ml)
Immunofluorescence (1 g/ml)
Immunoprecipitation (1 g/reaction)
包装
Please refer to vial label for lot-specific concentration.
外形
In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
分析说明
Positive Control
IMR90 or K562 cells
IMR90 or K562 cells
其他说明
Antibody should be titrated for optimal results in individual systems.
Dong, Z., et al. 1999. J. Biol. Chem.274, 19513.
Luo, G., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7376.
Petrini, J.H. 1999. Am. J. Hum. Genet.64, 1264.
Carney, J.P., et al. 1998. Cell93, 477.
Haber, J.E. 1998. Cell95, 583.
Nelms, B.E., et al. 1998. Science280, 590.
Maser, R.S., et al. 1997. Mol. Cell Biol.17, 6087.
Xiao, Y. and D.T. Weaver. 1997. Nucleic Acids Res.25, 2985.
Dolganov, G.M., et al. 1996. Mol. Cell Biol.16, 4832.
Petrini, J.H., et al. 1995. Genomics29, 80.
Luo, G., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7376.
Petrini, J.H. 1999. Am. J. Hum. Genet.64, 1264.
Carney, J.P., et al. 1998. Cell93, 477.
Haber, J.E. 1998. Cell95, 583.
Nelms, B.E., et al. 1998. Science280, 590.
Maser, R.S., et al. 1997. Mol. Cell Biol.17, 6087.
Xiao, Y. and D.T. Weaver. 1997. Nucleic Acids Res.25, 2985.
Dolganov, G.M., et al. 1996. Mol. Cell Biol.16, 4832.
Petrini, J.H., et al. 1995. Genomics29, 80.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
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储存分类代码
10-13 - German Storage Class 10 to 13
法规信息
新产品
此项目有
G Luo et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(13), 7376-7381 (1999-06-23)
The Mre11/Rad50 protein complex functions in diverse aspects of the cellular response to double-strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. Whereas genetic analyses in Saccharomyces cerevisiae have provided insight
B E Nelms et al.
Science (New York, N.Y.), 280(5363), 590-592 (1998-05-09)
A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand breaks (DSBs) in defined subnuclear volumes of human fibroblasts and DNA repair was visualized at those sites. The DSBs remained
The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response.
J H Petrini
American journal of human genetics, 64(5), 1264-1269 (1999-04-17)
Y Xiao et al.
Nucleic acids research, 25(15), 2985-2991 (1997-08-01)
Repair of DNA damage resulting in double-strand breaks (DSBs) is controlled by gene products executing homologous recombination or end-joining pathways. The MRE11 gene has previously been implicated in DSB repair in the yeast Saccharomyces cerevisiae . Here we have developed
R S Maser et al.
Molecular and cellular biology, 17(10), 6087-6096 (1997-10-07)
We previously identified a conserved multiprotein complex that includes hMre11 and hRad50. In this study, we used immunofluorescence to investigate the role of this complex in DNA double-strand break (DSB) repair. hMre11 and hRad50 form discrete nuclear foci in response
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