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Merck
CN

ST1204

Sigma-Aldrich

Anti-PGC-1α Rabbit pAb

liquid, Calbiochem®

别名:

PGC-1α Detection Antibody, Rabbit Anti-PGC-1α

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.43
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生物来源

rabbit

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

liquid

不包含

preservative

种属反应性

human, mouse, rat

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles

dilution

(Immunoblotting (not recommended)
Immunoprecipitation (1-2 µg/100-200 µg total protein))

同位素/亚型

IgG

运输

wet ice

储存温度

−70°C

靶向翻译后修饰

unmodified

基因信息

human ... PPARGC1A(10891)

一般描述

Protein G purified rabbit polyclonal antibody. Recognizes the ~113 kDa PGC-1α protein.
Recognizes the ~113 kDa PGC-1α protein in BAT cells.
This Anti-PGC-1α Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of PGC-1α.

免疫原

A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α

应用


Immunoblotting (not recommended)
Immunoprecipitation (1-2 g/100-200 g total protein)

外形

In 50 mM PBS

分析说明

Positive Control
Brown adipose tissue from mice exposed to cold

其他说明

Chang, J.S., et al. 2010. J. Biol. Chem. 285, 18039.
Zhang, Y., et al. 2009. J. Biol. Chem. 284, 32813.
Lai, L., et al. 2008. Genes Dev. 14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett. 582, 46.
Mazzucotelli, A., et al. 2007. Diabetes 10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem. 16, 16456.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Regulatory Review (Z)

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

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Elizabeth A Novak et al.
Frontiers in immunology, 14, 1231700-1231700 (2023-09-25)
We have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanism underlying downregulation of PGC1α expression and activity during IBD
Ryan W Baranowski et al.
iScience, 26(7), 107047-107047 (2023-06-26)
We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and RR18). Spaceflight reduced GSK3β content
Santosh Bhat et al.
Circulation. Heart failure, 12(3), e005529-e005529 (2019-02-26)
Proper dynamics of RNA polymerase II, such as promoter recruitment and elongation, are essential for transcription. PGC-1α (peroxisome proliferator-activated receptor [PPAR]-γ coactivator-1α), also termed PPARGC1a, is a transcriptional coactivator that stimulates energy metabolism, and PGC-1α target genes are downregulated in
Kennedy C Whitley et al.
Physiological reports, 8(14), e14517-e14517 (2020-07-31)
Calcineurin is a Ca2+ -dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increases the expression of proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α)
Susana Peralta et al.
Journal of cell science, 131(13) (2018-06-15)
Mutations in the mitochondrial inner membrane ATPase ATAD3A result in neurological syndromes in humans. In mice, the ubiquitous disruption of Atad3 (also known as Atad3a) was embryonic lethal, but a skeletal muscle-specific conditional knockout (KO) was viable. At birth, ATAD3

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