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ST1204

Anti-PGC-1α Rabbit pAb

Name: Anti-PGC-1α Rabbit pAb
Brand: MM

liquid, Calbiochem^®

别名:

PGC-1α Detection Antibody, Rabbit Anti-PGC-1α

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关于此项目

NACRES:

NA.43

UNSPSC Code:

12352203

Clone:

polyclonal

Species reactivity:

human, mouse, rat

Application:

—

Citations:

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属性

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

does not contain

preservative

species reactivity

human, mouse, rat

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

dilution

(Immunoblotting (not recommended)
Immunoprecipitation (1-2 µg/100-200 µg total protein))

isotype

IgG

shipped in

wet ice

storage temp.

−70°C

target post-translational modification

unmodified

Gene Information

human ... PPARGC1A(10891)

说明

General description

Protein G purified rabbit polyclonal antibody. Recognizes the ~113 kDa PGC-1α protein.

Recognizes the ~113 kDa PGC-1α protein in BAT cells.

This Anti-PGC-1α Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of PGC-1α.

Immunogen

A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α

Application

Immunoblotting (not recommended)
Immunoprecipitation (1-2 g/100-200 g total protein)

Physical form

In 50 mM PBS

Analysis Note

Positive Control
Brown adipose tissue from mice exposed to cold

Other Notes

Chang, J.S., et al. 2010. J. Biol. Chem. 285, 18039.
Zhang, Y., et al. 2009. J. Biol. Chem. 284, 32813.
Lai, L., et al. 2008. Genes Dev. 14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett. 582, 46.
Mazzucotelli, A., et al. 2007. Diabetes 10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem. 16, 16456.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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We have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanism underlying downregulation of PGC1α expression and activity during IBD

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Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.

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Proper dynamics of RNA polymerase II, such as promoter recruitment and elongation, are essential for transcription. PGC-1α (peroxisome proliferator-activated receptor [PPAR]-γ coactivator-1α), also termed PPARGC1a, is a transcriptional coactivator that stimulates energy metabolism, and PGC-1α target genes are downregulated in

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全球贸易项目编号

货号	GTIN
ST1204-100UL	04055977224108