04646
Hamamelitannin
≥98.0% (HPLC)
别名:
2-C-(Hydroxymethyl)-D-ribofuranose 2′,5-digallate, Hamamelofuranose 2′,5-digallate
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关于此项目
经验公式（希尔记法）:
C20H20O14
化学文摘社编号:
分子量:
484.36
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
207-416-3
MDL number:
InChI
1S/C20H20O14/c21-9-1-7(2-10(22)14(9)25)17(28)32-5-13-16(27)20(31,19(30)34-13)6-33-18(29)8-3-11(23)15(26)12(24)4-8/h1-4,13,16,19,21-27,30-31H,5-6H2/t13-,16-,19?,20-/m1/s1
InChI key
FEPAFOYQTIEEIS-IZUGRSKYSA-N
SMILES string
OC1O[C@H](COC(=O)c2cc(O)c(O)c(O)c2)[C@@H](O)[C@]1(O)COC(=O)c3cc(O)c(O)c(O)c3
assay
≥98.0% (HPLC)
form
powder or crystals
application(s)
food and beverages
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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General description
Hamamelitanninis a tannin derived from the bark and leaves of Hamamelis virginiana(witch hazel).
Application
Hamamelitannin can be used to study chromatography, aromatics, esters, hamamelis, heterocyclics, natural compounds, phenols, phytopharma standards, polyhydroxy compounds, and tannins. It also significantly reduces biofilm metabolic activity of the following bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Acinetobacter baumannii, and Candida albicans strains. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. It has been used in a study to determine that quorum-sensing inhibitors increase the success of antibiotic treatment by increasing the susceptibility of bacterial biofilms and/or by increasing host survival following infection.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
H Masaki et al.
Journal of dermatological science, 10(1), 25-34 (1995-07-01)
The protective activities of hamamelitannin (2',5-di-O-galloyl-hamamelose) in Hamamelis virginiana L. and its related compound, gallic acid, on damaged murine skin fibroblasts induced by UVB irradiation were investigated. In order to exclude the UV absorbing effect of the compounds, the protection
E Okochi et al.
Biological & pharmaceutical bulletin, 18(1), 49-52 (1995-01-01)
N-Nitrosodialkylamines are environmental alkylating carcinogens which are metabolically activated to alpha-hydroxy nitrosamines by cytochrome P450. The precise mechanism of their activation is not well understood, and a simplified chemical model for cytochrome P450 as a non-enzymatic system is useful for
Andreas Dauer et al.
Phytochemistry, 63(2), 199-207 (2003-04-25)
The genotoxic and antigenotoxic activities of catechin, hamamelitannin and two proanthocyanidin fractions prepared from the bark of Hamamelis virginiana L. were investigated in a human derived, metabolically competent hepatoma cell line (Hep G2) using single cell gel electrophoresis (SCGE) for
Hye Rhi Choi et al.
Phytotherapy research : PTR, 16(4), 364-367 (2002-07-12)
Peroxynitrite (ONOO(-)) is a cytotoxicant with strong oxidizing properties toward various cellular constituents, including sulphydryls, lipids, amino acids and nucleotides and can cause cell death, lipid peroxidation, carcinogenesis and aging. The aim of this study was to characterize ONOO(-) scavenging
Madanahally D Kiran et al.
Molecular pharmacology, 73(5), 1578-1586 (2008-03-04)
Staphylococci are a major health threat because of increasing resistance to antibiotics. An alternative to antibiotic treatment is preventing virulence by inhibition of bacterial cell-to-cell communication using the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP). In this work, we identified 2',5-di-O-galloyl-d-hamamelose (hamamelitannin)
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