18107
2-Methoxyestradiol
purum, ≥98.0% (HPLC)
别名:
1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol
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关于此项目
经验公式（希尔记法）:
C19H26O3
化学文摘社编号:
分子量:
302.41
UNSPSC Code:
51111800
MDL number:
Beilstein/REAXYS Number:
3147966
SMILES string
COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O
grade
purum
assay
≥98.0% (HPLC)
storage temp.
−20°C
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Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Lita S Suwandi et al.
Bioorganic & medicinal chemistry letters, 19(22), 6459-6462 (2009-09-29)
The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or improved antitumor activities and reduced metabolic liability compared to
Fabrice Jourdan et al.
Journal of medicinal chemistry, 53(7), 2942-2951 (2010-03-17)
The synthesis and antiproliferative activity of analogues of estradiol 3,17-O,O-bis-sulfamates (E2bisMATEs) are discussed. Modifications of the C-17 substituent reveal that an H-bond acceptor is essential for high antiproliferative activity. The local environment in which this H-bond acceptor lies can be
Jamshed H Shah et al.
Bioorganic & medicinal chemistry, 17(20), 7344-7352 (2009-09-19)
A novel series of 17-modified and 2,17-modified analogs of 2-methoxyestradiol (2ME2) were synthesized and characterized. These analogs were designed to retain or potentiate the biological activities of 2ME2 and have diminished metabolic liability. The analogs were evaluated for antiproliferative activity
SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms.
Abby Ho et al.
Bioorganic & medicinal chemistry letters, 16(13), 3383-3387 (2006-05-03)
The major estrogen metabolite 2-methoxyestradiol (2ME) has been shown to target tumor cells without severe side effects and is currently being evaluated in clinical trials for several types of cancer. Despite its promise for use in clinical setting, the mechanism(s)
Mathew P Leese et al.
Journal of medicinal chemistry, 51(5), 1295-1308 (2008-02-12)
The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed. 2-Methoxy-17beta-cyanomethylestra-1,3,5(10)-trien-3-ol ( 14), but not the related 2-ethyl derivative 7, and the related 3- O-sulfamates 8 and 15 display potent antiproliferative effects (MCF-7 GI 50
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