18107
2-Methoxyestradiol
purum, ≥98.0% (HPLC)
别名:
1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol
等级
purum
方案
≥98.0% (HPLC)
储存温度
−20°C
SMILES字符串
COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Jamshed H Shah et al.
Bioorganic & medicinal chemistry, 17(20), 7344-7352 (2009-09-19)
A novel series of 17-modified and 2,17-modified analogs of 2-methoxyestradiol (2ME2) were synthesized and characterized. These analogs were designed to retain or potentiate the biological activities of 2ME2 and have diminished metabolic liability. The analogs were evaluated for antiproliferative activity
Lita S Suwandi et al.
Bioorganic & medicinal chemistry letters, 19(22), 6459-6462 (2009-09-29)
The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or improved antitumor activities and reduced metabolic liability compared to
Fabrice Jourdan et al.
Journal of medicinal chemistry, 53(7), 2942-2951 (2010-03-17)
The synthesis and antiproliferative activity of analogues of estradiol 3,17-O,O-bis-sulfamates (E2bisMATEs) are discussed. Modifications of the C-17 substituent reveal that an H-bond acceptor is essential for high antiproliferative activity. The local environment in which this H-bond acceptor lies can be
Radek Gažák et al.
Journal of medicinal chemistry, 54(20), 7397-7407 (2011-09-21)
The synthesis of various silybin monogalloyl esters was developed, and their antiangiogenic activities were evaluated in a variety of in vitro tests with human umbilical vein endothelial cells (HUVECs). A structure-activity relationship (SAR) study found the regioselectivity of the silybin
Gregory E Agoston et al.
Bioorganic & medicinal chemistry, 15(24), 7524-7537 (2007-10-04)
A series of 16-modified 2-methoxyestradiol analogs were synthesized and evaluated for antiproliferative activity toward HUVEC and MDA-MB-231 cells, and for susceptibility to conjugation. In addition, the estrogenicity of these analogs was accessed by measuring cell proliferation of the estrogen-dependent cell
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