18107
2-Methoxyestradiol
purum, ≥98.0% (HPLC)
别名:
1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C19H26O3
化学文摘社编号:
分子量:
302.41
UNSPSC Code:
51111800
MDL number:
Beilstein/REAXYS Number:
3147966
grade
purum
assay
≥98.0% (HPLC)
storage temp.
−20°C
SMILES string
COc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2cc1O
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Mathew P Leese et al.
Journal of medicinal chemistry, 51(5), 1295-1308 (2008-02-12)
The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed. 2-Methoxy-17beta-cyanomethylestra-1,3,5(10)-trien-3-ol ( 14), but not the related 2-ethyl derivative 7, and the related 3- O-sulfamates 8 and 15 display potent antiproliferative effects (MCF-7 GI 50
SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms.
Abby Ho et al.
Bioorganic & medicinal chemistry letters, 16(13), 3383-3387 (2006-05-03)
The major estrogen metabolite 2-methoxyestradiol (2ME) has been shown to target tumor cells without severe side effects and is currently being evaluated in clinical trials for several types of cancer. Despite its promise for use in clinical setting, the mechanism(s)
Christian Bubert et al.
Journal of medicinal chemistry, 50(18), 4431-4443 (2007-08-19)
Estradiol-3,17-O,O-bis-sulfamates inhibit steroid sulfatase (STS), carbonic anhydrase (CA), and, when substituted at C-2, cancer cell proliferation and angiogenesis. C-2 Substitution and 17-sulfamate replacement of the estradiol-3,17-O,O-bis-sulfamates were explored with efficient and practical syntheses developed. Evaluation against human cancer cell lines