22128
Cefotaxime sodium salt 钠盐
≥98.0% (TLC)
别名:
Cefotaxim sodium salt 钠盐
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关于此项目
经验公式（希尔记法）:
C16H16N5NaO7S2
化学文摘社编号:
分子量:
477.45
EC Number:
264-915-9
UNSPSC Code:
51101500
MDL number:
Beilstein/REAXYS Number:
5711411
assay
≥98.0% (TLC)
impurities
≤5% water
solubility
H2O: 50 mg/mL, clear, light yellow
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI
1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI key
AZZMGZXNTDTSME-JUZDKLSSSA-M
General description
Chemical structure: β-lactam
Biochem/physiol Actions
Mode of Action: Inhibits bacterial cell wall synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
This product has been replaced by C7912-SIGMA | Cefotaxime sodium salt potency: 916-964 μg per mg
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法规信息
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Laetitia Betelli et al.
Talanta, 184, 210-218 (2018-04-21)
The accurate identification of β-lactamases produced by Enterobacteriaceae is a major challenge in clinical laboratories in order to optimize antimicrobial treatment and patient care. We describe here a rapid voltammetric-based method to detect and to discriminate β-lactamase activity in Enterobacteriaceae
Carola E H Rosenkilde et al.
Nature communications, 10(1), 618-618 (2019-02-08)
Antibiotic resistance is a major challenge to global public health. Discovery of new antibiotics is slow and to ensure proper treatment of bacterial infections new strategies are needed. One way to curb the development of antibiotic resistance is to design