22128
Cefotaxime sodium salt 钠盐
≥98.0% (TLC)
别名:
Cefotaxim sodium salt 钠盐
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关于此项目
经验公式（希尔记法）:
C16H16N5NaO7S2
化学文摘社编号:
分子量:
477.45
Beilstein:
5711411
EC 号:
MDL编号:
UNSPSC代码:
51101500
方案
≥98.0% (TLC)
杂质
≤5% water
溶解性
H2O: 50 mg/mL, clear, light yellow
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI
1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI key
AZZMGZXNTDTSME-JUZDKLSSSA-M
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一般描述
Chemical structure: ß-lactam
生化/生理作用
Mode of Action: Inhibits bacterial cell wall synthesis.
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
其他说明
Broad spectrum third generation cephalosporin antibiotic.
This product has been replaced by C7912-SIGMA | Cefotaxime sodium salt potency: 916-964 μg per mg
法规信息
新产品
此项目有
Laetitia Betelli et al.
Talanta, 184, 210-218 (2018-04-21)
The accurate identification of β-lactamases produced by Enterobacteriaceae is a major challenge in clinical laboratories in order to optimize antimicrobial treatment and patient care. We describe here a rapid voltammetric-based method to detect and to discriminate β-lactamase activity in Enterobacteriaceae
Carola E H Rosenkilde et al.
Nature communications, 10(1), 618-618 (2019-02-08)
Antibiotic resistance is a major challenge to global public health. Discovery of new antibiotics is slow and to ensure proper treatment of bacterial infections new strategies are needed. One way to curb the development of antibiotic resistance is to design
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