32991
拉诺康唑
VETRANAL®, analytical standard
别名:
2-[4-(2-氯苯基)-1,3-二硫戊环-2-亚基]-2-咪唑-1-基-乙腈
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关于此项目
经验公式（希尔记法）:
C14H10ClN3S2
化学文摘社编号:
分子量:
319.83
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
ZRTQSJFIDWNVJW-WYMLVPIESA-N
SMILES string
Clc1ccccc1C2CS\C(S2)=C(\C#N)n3ccnc3
InChI
1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Quality Level
General description
Lanoconazole is a member of the imidazole family and an antifungal agent, which finds applications as an antidermatophytic drug.
Application
Lanoconazole may be used as a reference standard in the determination of lanoconazole in pharmaceutical formulations using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Fisher's Contact Dermatitis (2008)
Y Nishiyama et al.
Journal of electron microscopy, 50(1), 41-49 (2001-04-09)
Synergism of lysozyme with the imidazole antifungal lanoconazole (LCZ) has been demonstrated in vitro against Candida albicans. To determine the mechanism of the synergistic action, the effects of subinhibitory concentrations of lysozyme (50 microg ml(-1)) and LCZ (1.25 microg ml(-1))
M A Ghannoum et al.
Mycoses, 53(4), 311-313 (2009-05-09)
The objective of this study was to compare the antifungal activity of terbinafine (TERB) with that of lanoconazole (LAN). Test isolates, which were clinical isolates of Japanese origin, included 10 strains each of Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum.
A Phani Kumar et al.
Journal of pharmaceutical and biomedical analysis, 50(3), 535-537 (2009-06-03)
An isocratic normal phase high-performance liquid chromatographic (NP-HPLC) method has been developed and validated for the quantitation of Z-isomer in lanoconazole. Separation was achieved with a Thermo Hypersil Silica column. The ratio of 2-propanol, n-hexane and triethylamine in the mobile
Allergic contact dermatitis due to both lanoconazole and neticonazole ointments.
Y Umebayashi et al.
Contact dermatitis, 44(1), 48-49 (2001-01-13)
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