38399
氟磷酸二异丙酯
≥97.0% (GC)
别名:
DFP, DIFP, 二异丙基氟磷酸酯, 氟代磷酸二异丙酯
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关于此项目
线性分子式:
[(CH3)2CHO]2POF
化学文摘社编号:
分子量:
184.15
EC Number:
200-247-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1723307
MDL number:
vapor pressure
0.58 mmHg ( 20 °C)
assay
≥97.0% (GC)
refractive index
n20/D 1.385 (lit.)
bp
62 °C/9 mmHg (lit.)
mp
−82 °C (lit.)
density
1.06 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
CC(C)OP(F)(=O)OC(C)C
InChI
1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
InChI key
MUCZHBLJLSDCSD-UHFFFAOYSA-N
Gene Information
human ... ACHE(43), PTGS1(5742), PTGS2(5743)
Biochem/physiol Actions
丝氨酸蛋白酶和乙酰胆碱酯酶的强效抑制剂；抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases); Inhibition of carboxypeptidase but not DAP I
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
J.K. McDonald et al.
Methods in Enzymology, XV(B), 275-275 (1972)
J.A. Cohen et al.
Methods in Enzymology, XI, 686-686 (1967)
A V Terry et al.
Neurotoxicology and teratology, 34(1), 1-8 (2011-10-26)
The acute toxicity of organophosphates (OPs) has been studied extensively; however, much less attention has been given to the subject of repeated exposures that are not associated with overt signs of toxicity (i.e., subthreshold exposures). The objective of this study