38399
氟磷酸二异丙酯
≥97.0% (GC)
别名:
DFP, DIFP, 二异丙基氟磷酸酯, 氟代磷酸二异丙酯
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关于此项目
线性分子式:
[(CH3)2CHO]2POF
化学文摘社编号:
分子量:
184.15
EC Number:
200-247-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1723307
MDL number:
InChI key
MUCZHBLJLSDCSD-UHFFFAOYSA-N
InChI
1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
SMILES string
CC(C)OP(F)(=O)OC(C)C
vapor pressure
0.58 mmHg ( 20 °C)
assay
≥97.0% (GC)
refractive index
n20/D 1.385 (lit.)
bp
62 °C/9 mmHg (lit.)
mp
−82 °C (lit.)
density
1.06 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Gene Information
human ... ACHE(43), PTGS1(5742), PTGS2(5743)
Biochem/physiol Actions
丝氨酸蛋白酶和乙酰胆碱酯酶的强效抑制剂；抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases); Inhibition of carboxypeptidase but not DAP I
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
J.K. McDonald et al.
Methods in Enzymology, XV(B), 275-275 (1972)
A molecular probe for the highly selective chromogenic detection of DFP, a mimic of Sarin and Soman nerve agents.
Raúl Gotor et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(43), 11994-11997 (2011-09-17)
Yonggang Li et al.
Toxicology and applied pharmacology, 262(2), 194-204 (2012-05-16)
Current medical countermeasures against organophosphate (OP) nerve agents are effective in reducing mortality, but do not sufficiently protect the CNS from delayed brain damage and persistent neurological symptoms. In this study, we examined the efficacy of neuregulin-1 (NRG-1) in protecting
J.A. Cohen et al.
Methods in Enzymology, XI, 686-686 (1967)
A V Terry et al.
Neurotoxicology and teratology, 34(1), 1-8 (2011-10-26)
The acute toxicity of organophosphates (OPs) has been studied extensively; however, much less attention has been given to the subject of repeated exposures that are not associated with overt signs of toxicity (i.e., subthreshold exposures). The objective of this study
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