484407
1-甲氧基-2-丙醇
≥99.5%
别名:
DOWANOL® PM, 丙二醇单甲醚, 丙二醇甲醚
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关于此项目
线性分子式:
CH3CH(OH)CH2OCH3
化学文摘社编号:
分子量:
90.12
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
EC Number:
203-539-1
Beilstein/REAXYS Number:
1731270
MDL number:
Assay:
≥99.5%
Bp:
118-119 °C (lit.)
Vapor pressure:
10.9 mmHg ( 25 °C)
产品名称
1-甲氧基-2-丙醇, ≥99.5%
InChI key
ARXJGSRGQADJSQ-UHFFFAOYSA-N
InChI
1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3
SMILES string
CC(O)COC
vapor density
3.12 (vs air)
vapor pressure
10.9 mmHg ( 25 °C)
product line
ReagentPlus®
assay
≥99.5%
form
liquid
autoignition temp.
532 °F
expl. lim.
13.8 %
greener alternative product characteristics
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sustainability
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impurities
≤0.001% water
refractive index
n20/D 1.403 (lit.)
bp
118-119 °C (lit.)
mp
-97 °C
solubility
water: miscible
density
0.916 g/mL at 25 °C (lit.)
application(s)
microbiology
greener alternative category
, Aligned
Quality Level
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General description
1-甲氧基-2-丙醇(丙二醇甲醚，PGME)，是一种甘醇醚，可通过在ZnMgAl（锌-镁-铝）催化剂存在下由环氧丙烷与甲醇反应进行合成。它在不同土壤类型中的微生物降解已被研究。通过对F344大鼠和B6C3F1小鼠的吸入研究，已得到PGME的口服参考剂量（RfD）和吸入参考浓度（RfC）值。
我们致力于为您提供更环保的替代产品，以符合“绿色化学的 12 项原则”的一项或多项原则要求。单醚，特别是丙二醇甲醚（PGME）作为一种无污染溶剂已广泛应用于制药、化工和化装品行业的精细有机合成应用中，符合“更安全的溶剂和辅助剂”的要求。 点击此处了解更多信息。
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3 - STOT SE 3
target_organs
Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
88.7 °F - closed cup - (External MSDS)
flash_point_c
31.5 °C - closed cup - (External MSDS)
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Influence of acid-base properties of ZnMgAl-mixed oxides for the synthesis of 1-methoxy-2-propanol.
Cheng W, et al.
Applied Clay Science, 42(1), 111-115 (2008)
Biodegradation of glycol ethers in soil.
Gonsior SJ and West RJ.
Environmental Toxicology and Chemistry / Setac, 14(8), 1273-1279 (1995)
S R Vink et al.
Regulatory toxicology and pharmacology : RTP, 58(1), 64-71 (2010-04-17)
REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in
Juergen Brieger et al.
Toxicology letters, 177(2), 138-143 (2008-02-26)
To evaluate the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German
W R Berendsen et al.
Biotechnology and bioengineering, 95(5), 883-892 (2006-08-29)
Lipase-catalyzed kinetic resolution of racemates is a popular method for synthesis of chiral synthons. Most of these resolutions are reversible equilibrium limited reactions. For the first time, an extensive kinetic model is proposed for kinetic resolution reactions, which takes into
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