生物来源
Rosemarinus officinalis L. leaves
质量水平
等级
analytical standard
方案
≥98.0% (HPLC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
food and beverages
包装形式
neat
储存温度
−20°C
SMILES字符串
CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
InChI
1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChI key
XUSYGBPHQBWGAD-PJSUUKDQSA-N
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一般描述
Carnosol is a naturally occurring phyto polyphenolor phenolic diterpene, found in rosemary, which can show a broad spectrum of applications as a an antioxidant, anticancer agent and anti-inflammatory agent.
Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
一种具有抗氧化和抗癌活性的酚类二萜。
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
其他说明
This compound is commonly found in plants of the genus: salvia
警示用语：
Warning
危险声明
预防措施声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Carnosol: a promising anti-cancer and anti-inflammatory agent
Johnson.JJ
Cancer Letters, 305, 1-7 (2011)
Chien-chung Chen et al.
Acta pharmacologica Sinica, 32(1), 62-69 (2010-12-15)
To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells. Human hepatoma cell line HepG2 were exposed to rosemarry essential oil or carnosol. Cell viability was measured using an Alamar
Pi-wen Zhao et al.
Biological & pharmaceutical bulletin, 35(11), 1947-1955 (2012-09-14)
Antioxidant action is critical for maintaining the normal cardiovascular function and vascular endothelial cell is an important target of estrogen action through estrogen receptor (ER) pathway. This study is carried out to explore the antioxidant effect of carnosol in bovine
Shiu-Chen Huang et al.
Biochemical pharmacology, 69(2), 221-232 (2005-01-04)
Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties. In our studies, carnosol inhibited the invasion of highly metastatic mouse melanoma B16/F10 cells in vitro. First, the antimetastatic potentials of
Trude Rakel Balstad et al.
Molecular nutrition & food research, 55(2), 185-197 (2010-09-10)
Cytoprotective gene products, e.g. phase II - and antioxidant enzymes, are important in cellular redox homeostasis. A common feature of these genes is binding sites for transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2), named electrophile response elements (EpREs) within
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