69412
CDP-glycerol sodium salt
≥95.0% (HPLC)
别名:
Cytidine 5′-(trihydrogen diphosphate) P′-(2,3-dihydroxypropyl) ester sodium salt, Cytidine 5′-diphosphate glycerol sodium salt, Cytidine 5′-pyrophosphate 2,3-dihydroxypropyl ester sodium salt
InChI
1S/C9H15N3O9P2.C3H8O3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-23(18)21-22(16)17;4-1-3(6)2-5/h1-2,4,6-8,13-14,22-23H,3H2,(H,16,17)(H2,10,11,15);3-6H,1-2H2
InChI key
DZUKQJZKHOQCIU-UHFFFAOYSA-N
SMILES string
O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1COP(OP(O)(OCC(O)CO)=O)(O)=O
assay
≥95.0% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
CDP-glycerol is a substrate for manganese-dependent ADP-ribose/CDP-alcohol diphosphatase and is part of the purine metabolism and glycerophospholipid metabolic pathways.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
H G Rittenhouse et al.
Journal of neurochemistry, 36(3), 991-999 (1981-03-01)
Enzymatic hydrolysis of the pyrophosphate bond of CDP-diglyceride (CDP-DG), previously shown to occur in bacteria, is demonstrable in mammalian tissues. Activity was enriched in a lysosomal fraction obtained from guinea pig cerebral cortex and was purified 92-fold relative to the
Stephanie Brown et al.
Chemistry & biology, 15(1), 12-21 (2008-01-25)
Resistance to every family of clinically used antibiotics has emerged, and there is a pressing need to explore unique antibacterial targets. Wall teichoic acids (WTAs) are anionic polymers that coat the cell walls of many Gram-positive bacteria. Because WTAs play
Stephanie Brown et al.
Annual review of microbiology, 67, 313-336 (2013-09-13)
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial roles in cell shape determination, regulation of cell division, and other fundamental aspects of gram-positive bacterial physiology.
Volker Winstel et al.
mBio, 5(2), e00869-e00869 (2014-04-10)
ABSTRACT The major clonal lineages of the human pathogen Staphylococcus aureus produce cell wall-anchored anionic poly-ribitol-phosphate (RboP) wall teichoic acids (WTA) substituted with d-Alanine and N-acetyl-d-glucosamine. The phylogenetically isolated S. aureus ST395 lineage has recently been found to produce a unique
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(46), 18909-18914 (2012-10-03)
Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d-alanylation, α-O-GlcNAcylation, and β-O-GlcNAcylation. Here we describe the discovery and biochemical characterization of a unique glycosyltransferase, TarS, that attaches
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