80693
(±)-2-Propyl-4-pentenoic acid
analytical standard
别名:
2-Allylpentanoic acid
等级
analytical standard
质量水平
方案
≥97.0% (GC)
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical
包装形式
neat
储存温度
2-8°C
SMILES字符串
C=CCC(CCC)C(O)=O
InChI
1S/C8H14O2/c1-3-5-7(6-4-2)8(9)10/h3,7H,1,4-6H2,2H3,(H,9,10)
InChI key
UMYDNZXEHYSVFY-UHFFFAOYSA-N
一般描述
2-Propyl-4-pentenoic acid is the main teratogenic and hepatotoxic metabolite of valproic acid, an anticonvulsant prescribed for treating seizures and for the maintenance phase of bipolar disorders.
应用
2-Propyl-4-pentenoic acid may be used as an analytical standard for the determination of the analyte in biological samples by various chromatography-based techniques.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Prophylactic efficacy of lithium, valproic acid, and carbamazepine in the maintenance phase of bipolar disorder: a naturalistic study
Peselow ED, et al.
International Clinical Psychopharmacology, 31(4), 218-223 (2016)
Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS
Cheng H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 850(1-2), 206-212 (2007)
Cheng Chang et al.
Molecular pharmacology, 94(2), 823-833 (2018-06-02)
Kynurenic acid (KYNA) plays a significant role in maintaining normal brain function, and abnormalities in KYNA levels have been associated with various central nervous system disorders. Confirmation of its causality in human diseases requires safe and effective modulation of central
Wojciech Jawień et al.
Pharmacological reports : PR, 69(2), 340-349 (2017-02-12)
Valproic acid (VPA) is a first-line antiepileptic drug. It is used in the treatment of many different types of partial and generalized epileptic seizures. Though the clinical pharmacokinetics of VPA has been well defined, information about pharmacokinetics after overdoses is
Zhuo-Jia Chen et al.
Seizure, 21(2), 110-117 (2011-11-08)
Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy. Although there are many reports of adverse effects of VPA, studies focusing on the concentration-response relationships of VPA
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