81619
四氢嘧啶
≥95.0% (HPLC)
别名:
(S)-2-甲基-1,4,5,6-四氢嘧啶-4-羧酸, 刺激物（B）
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关于此项目
经验公式（希尔记法）:
C6H10N2O2
化学文摘社编号:
分子量:
142.16
Beilstein:
7288977
EC 号:
MDL编号:
UNSPSC代码:
24112111
PubChem化学物质编号:
NACRES:
NA.21
质量水平
方案
≥95.0% (HPLC)
表单
powder
分子量
142.16 g/mol
储存条件
dry at room temperature
颜色
white
溶解性
methanol: soluble 10 mg/mL, clear, colorless to almost colorless
SMILES字符串
CC1=N[C@@H](CCN1)C(O)=O
InChI
1S/C6H10N2O2/c1-4-7-3-2-5(8-4)6(9)10/h5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
InChI key
WQXNXVUDBPYKBA-YFKPBYRVSA-N
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一般描述
四氢嘧啶(Ectoine)， 全称4,5,6-四氢-2-甲基-4-嘧啶羧酸， 是一种两性氨基酸衍生物，作为相容性渗透保护溶质， 由好氧型、化能异养型和嗜盐性细菌生产， 抵抗渗透压胁迫、辐射和其他不利的 环境条件。
应用
该 四氢嘧啶的实际应用包括酶稳定、 抗炎处理、神经退行性疾病预防和其他 治疗用途。
生化/生理作用
四氢嘧啶可用作酶稳定剂，在温度变化下维持水化和减少酶变性。还可提高双链DNA的高温稳定性。
其他说明
酶和生物大分子的稳定剂
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Adam Bownik et al.
Arhiv za higijenu rada i toksikologiju, 67(4), 260-265 (2016-12-30)
Ectoine is a compatible water molecule-binding solute (osmoprotectant) produced by several bacterial species in response to osmotic stress and unfavourable environmental conditions. This amino acid derivative can accumulate inside cells at high concentrations without interfering with natural processes and can
K. Lippert, E.A. Galinski
Applied Microbiology and Biotechnology, 37, 61-61 (1992)
Ruediger Graf et al.
Clinics in dermatology, 26(4), 326-333 (2008-08-12)
The protective properties of ectoine, formerly described for only extremophilic microorganisms, can be transferred to human skin. Our present data show that the compatible solute ectoine protects the cellular membrane from damage caused by surfactants. Transepidermal water loss measurements in
Ralf Spindler et al.
Cryobiology, 64(3), 250-260 (2012-02-22)
Cellular response during the freeze-thaw process strongly affects the cryopreservation outcome including cell morphology and cell viability. Cryomicroscopy was used to individually analyze the osmotic response of human pulmonary microvascular endothelial cells (HPMECs) during slow cooling (1 °C/min) to -60
Jens Smiatek et al.
Biophysical chemistry, 160(1), 62-68 (2011-10-22)
We have performed Molecular Dynamics simulations of ectoine, hydroxyectoine and urea in explicit solvent. Special attention has been spent on the local surrounding structure of water molecules. Our results indicate that ectoine and hydroxyectoine are able to accumulate more water
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