89193
胆钙化醇
tested according to Ph. Eur.
别名:
胆钙化醇, (+)-维生素 D3, 活化7-脱氢胆固醇, 活化7-脱氢胆甾醇, 胆骨化醇
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关于此项目
经验公式（希尔记法）:
C27H44O
化学文摘社编号:
分子量:
384.64
EC Number:
200-673-2
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2339331
MDL number:
agency
tested according to Ph. Eur.
mp
83-86 °C (lit.)
application(s)
pharmaceutical (small molecule)
storage temp.
2-8°C
SMILES string
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI
1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
Biochem/physiol Actions
维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。
维生素 D 通过调控正常细胞和癌细胞增殖和分化的受体而发挥作用。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Negar Tabatabaei et al.
The Journal of nutrition, 144(12), 1994-2001 (2014-10-25)
Whether there is a dose-dependent effect of maternal dietary cholecalciferol during pregnancy on maternal glucose tolerance is unknown. In addition, circulating osteocalcin is increased by 1,25-dihydroxyvitamin D [1,25(OH)2D] and may improve glucose homeostasis. This study was designed to test whether
C Jackson et al.
QJM : monthly journal of the Association of Physicians, 100(4), 185-192 (2007-02-20)
We evaluated the effect of supplementation with vitamin D(3) (excluding the potential effect of calcium supplementation) on the risk of fall and fracture, primarily in postmenopausal women, using a systematic literature review of MEDLINE, EMBASE, BIOSIS and the Cochrane Database
G E Lester
Federation proceedings, 45(10), 2524-2527 (1986-09-01)
Transplacental movement of calcium from mother to fetus is essential for normal fetal development. In most species, fetal plasma calcium levels are higher than maternal levels at term. The role of cholecalciferol metabolites, with specific emphasis on 1,25-dihydroxycholecalciferol (1,25(OH)2D), in