90567
安替吡啉
reference material
别名:
2,3-二甲基-1-苯基-3-吡唑啉-5-酮, 非那宗
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经验公式（希尔记法）:
C11H12N2O
化学文摘社编号:
分子量:
188.23
EC Number:
200-486-6
UNSPSC Code:
77101502
PubChem Substance ID:
Beilstein/REAXYS Number:
157775
MDL number:
InChI
1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
InChI key
VEQOALNAAJBPNY-UHFFFAOYSA-N
SMILES string
CN1N(C(=O)C=C1C)c2ccccc2
grade
reference material
assay
≥98.5% (qNMR), ≥99.0% (GC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤0.5% water
mp
109-111 °C (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Gene Information
human ... PTGS1(5742)
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
F Pautet et al.
Pathologie-biologie, 33(7), 777-780 (1985-09-01)
Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite
Drugs and the liver. Part II. The role of the antipyrine test in drug metabolism studies.
M Hartleb
Biopharmaceutics & drug disposition, 12(8), 559-570 (1991-11-01)
[The use of antipyrine for assessing the enzymatic activity of the liver monooxygenase system (a review of the literature)].
A Kh Ashirmetov et al.
Laboratornoe delo, (1)(1), 16-20 (1990-01-01)
L B Zavodnik et al.
Farmakologiia i toksikologiia, 52(3), 95-101 (1989-05-01)
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical
A P Viktorov et al.
Farmakologiia i toksikologiia, 53(1), 74-77 (1990-01-01)
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors
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