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Merck
CN

93938

芦荟大黄素

analytical standard

别名:

1,8-二羟基-3-(羟甲基)蒽甲苯, 1,8-二羟基3-羟甲基蒽甲苯, 3-羟甲基白杨嗪, 弹力素

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关于此项目

经验公式(希尔记法):
C15H10O5
化学文摘社编号:
分子量:
270.24
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-571-7
Beilstein/REAXYS Number:
2059062
MDL number:
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grade

analytical standard

Quality Level

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

light orange to dark orange

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

InChI key

YDQWDHRMZQUTBA-UHFFFAOYSA-N

General description

Aloe-emodin is a hydroxyanthraquinone and an active component present in Aloe vera leaves and root/rhizome of Rheum palmatum, possessing specific in vitro and in vivo antineuroectodermal tumor activity.

Application

Aloe-emodin may be used as a reference standard in the determination of aloe-emodin in Aloe vera extracts and commercial formulations using high-performance liquid chromatography (HPLC) coupled with tandem UV absorption and fluorimetric detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

复方泻药/泻药;通过释放内源性乙酰胆碱来增加肠道平滑肌的收缩。抗肿瘤活性与活性氧簇 (ROS) 产生增加相关,活性氧簇反过来降低线粒体跨膜电位,从而诱导渗透性转换,启动一系列事件,最终导致细胞凋亡。遗传毒性和致突变性似乎是由于芦荟大黄素抑制了拓扑异构酶II的活性。

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This compound is commonly found in plants of the genus: aloe


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Determination of aloe emodin in Aloe vera extracts and commercial formulations by HPLC with tandem UV absorption and fluorescence detection.
Mandrioli R, et al.
Food Chemistry, 126(1), 387-393 (2011)
Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Lee Z-H, et al.
European Journal of Pharmacology, 431(3), 287-295 (2001)
Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
Pecere T, et al.
Cancer Research, 60(11), 2800-2804 (2000)



全球贸易项目编号

货号GTIN
93938-10MG04061833283424