L5783
利多卡因 N -溴乙烷
analytical standard, for drug analysis
别名:
N -（2,6-二甲基苯基氨甲酰基甲基）三乙基溴化铵, QX-314
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关于此项目
经验公式（希尔记法）:
C16H27BrN2O
CAS Number:
分子量:
343.30
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
SMILES字符串
[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChI key
DLHMKHREUTXMCH-UHFFFAOYSA-N
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应用
利多卡因 N -溴乙烷已作为标准品，采用比色法在体外研究利多卡因 N-乙基溴对乳腺癌细胞的去甲基化作用 。
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
生化/生理作用
不具有膜渗透性的利多卡因的四元衍生物。阻断快速Na+操作依赖性动作电位和电压依赖性非失活性 Na+电导。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Richard I Kuo et al.
Neuron, 73(5), 1016-1027 (2012-03-13)
Both human speech and animal vocal signals contain frequency-modulated (FM) sounds. Although central auditory neurons that selectively respond to the direction of frequency modulation are known, the synaptic mechanisms underlying the generation of direction selectivity (DS) remain elusive. Here we
W G Regehr et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(11), 4202-4223 (1992-11-01)
The spatial and temporal dynamics of many electrophysiological and biochemical processes in nerve cells are in turn dependent on the concentration dynamics of the second messenger calcium. We have used microfluorimetry of the calcium indicator fura-2 (Grynkiewicz et al., 1985)
Arthur Beyder et al.
Circulation, 125(22), 2698-2706 (2012-05-09)
Na(V)1.5 is a mechanosensitive voltage-gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties. Mechanosensitivity of Na(V)1.5 was tested in voltage-clamped
Pishan Chang et al.
eNeuro, 7(5) (2020-08-08)
When skin afferents are activated, the sensory signals are transmitted to the spinal cord and eventually reach the primary somatosensory cortex (S1), initiating the encoding of the sensory percept in the brain. While subsets of primary afferents mediate specific somatosensory
Hossain Md Zakir et al.
PloS one, 7(9), e44023-e44023 (2012-09-11)
Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypothesized that the level
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