L5783
利多卡因 N -溴乙烷
analytical standard, for drug analysis
别名:
N -（2,6-二甲基苯基氨甲酰基甲基）三乙基溴化铵, QX-314
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关于此项目
经验公式（希尔记法）:
C16H27BrN2O
化学文摘社编号:
分子量:
343.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
SMILES string
[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C
InChI key
DLHMKHREUTXMCH-UHFFFAOYSA-N
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Application
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
利多卡因 N -溴乙烷已作为标准品，采用比色法在体外研究利多卡因 N-乙基溴对乳腺癌细胞的去甲基化作用 。
Biochem/physiol Actions
不具有膜渗透性的利多卡因的四元衍生物。阻断快速Na+操作依赖性动作电位和电压依赖性非失活性 Na+电导。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro
Lirk.P, et al.
British Journal of Anaesthesia, 113 (2014)
Kimbria J Blake et al.
Nature communications, 9(1), 37-37 (2018-01-04)
The hallmark of many bacterial infections is pain. The underlying mechanisms of pain during live pathogen invasion are not well understood. Here, we elucidate key molecular mechanisms of pain produced during live methicillin-resistant Staphylococcus aureus (MRSA) infection. We show that
D P Roberson et al.
British journal of pharmacology, 164(1), 48-58 (2011-04-05)
We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves co-administration of
Huan Luo et al.
Frontiers in neuroanatomy, 11, 115-115 (2018-01-10)
Layer 2/3 (L2/3) excitatory neurons in the neocortex make major contributions to corticocortical connections and therefore function to integrate information across cortical areas and hemispheres. Recent evidence suggests that excitatory neurons in L2/3 can have different properties. Sparse evidence from
Christian Brenneis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 315-326 (2013-01-04)
Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly
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