L5783
利多卡因 N -溴乙烷
analytical standard, for drug analysis
别名:
N -（2,6-二甲基苯基氨甲酰基甲基）三乙基溴化铵, QX-314
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关于此项目
经验公式（希尔记法）:
C16H27BrN2O
化学文摘社编号:
分子量:
343.30
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
SMILES字符串
[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChI key
DLHMKHREUTXMCH-UHFFFAOYSA-N
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应用
利多卡因 N -溴乙烷已作为标准品，采用比色法在体外研究利多卡因 N-乙基溴对乳腺癌细胞的去甲基化作用 。
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
生化/生理作用
不具有膜渗透性的利多卡因的四元衍生物。阻断快速Na+操作依赖性动作电位和电压依赖性非失活性 Na+电导。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kimbria J Blake et al.
Nature communications, 9(1), 37-37 (2018-01-04)
The hallmark of many bacterial infections is pain. The underlying mechanisms of pain during live pathogen invasion are not well understood. Here, we elucidate key molecular mechanisms of pain produced during live methicillin-resistant Staphylococcus aureus (MRSA) infection. We show that
Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro
Lirk.P, et al.
British Journal of Anaesthesia, 113 (2014)
Ricardo E Rivera-Acevedo et al.
Anesthesiology, 114(6), 1425-1434 (2011-04-20)
Transient receptor potential vanilloid subfamily member 1 (TRPV1) channels are important integrators of noxious stimuli with pronounced expression in nociceptive neurons. The experimental local anesthetic, QX-314, a quaternary (i.e., permanently charged) lidocaine derivative, recently has been shown to interact with
Hossain Md Zakir et al.
PloS one, 7(9), e44023-e44023 (2012-09-11)
Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypothesized that the level
D P Roberson et al.
British journal of pharmacology, 164(1), 48-58 (2011-04-05)
We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves co-administration of
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