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S5632

磺胺甲二唑

Name: 磺胺甲二唑
Brand: SIAL

analytical standard, ≥99% (HPLC)

别名:

4-氨基-N-(5-甲基-1,3,4-噻二唑-2-基)苯磺酰胺, N¹-(5-甲基-1,3,4-噻二唑-2-基)磺胺

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关于此项目

经验公式（希尔记法）:

C₉H₁₀N₄O₂S₂

化学文摘社编号:

144-82-1

分子量:

270.33

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329824459

EC Number:

205-641-1

Beilstein/REAXYS Number:

255002

MDL number:

MFCD00053363

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grade

analytical standard

Quality Level

100

agency

EPA 1694

assay

≥99% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1

InChI

1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

InChI key

VACCAVUAMIDAGB-UHFFFAOYSA-N

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General description

Sulfamethizole is an antibacterial drug used in the treatment of the urinary tract infections.

Application

Sulfamethizole may be used as a reference standard to examine the antibiotic remnants in honey by multianalyte/multiclass ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P280

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Free-radical-induced oxidative and reductive degradation of sulfa drugs in water: absolute kinetics and efficiencies of hydroxyl radical and hydrated electron reactions.

Stephen P Mezyk et al.

The journal of physical chemistry. A, 111(37), 9019-9024 (2007-08-25)

Absolute rate constants and degradation efficiencies for hydroxyl radical and hydrated electron reactions with four different sulfa drugs in water have been evaluated using a combination of electron pulse radiolysis/absorption spectroscopy and steady-state radiolysis/high-performance liquid chromatography measurements. For sulfamethazine, sulfamethizole

(14)N NQR, (1)H NMR and DFT/QTAIM study of hydrogen bonding and polymorphism in selected solid 1,3,4-thiadiazole derivatives.

Janez Seliger et al.

Physical chemistry chemical physics : PCCP, 12(40), 13007-13019 (2010-09-08)

The 1,3,4-thiadiazole derivatives (2-amino-1,3,4-thiadiazole, acetazolamide, sulfamethizole) have been studied experimentally in the solid state by (1)H-(14)N NQDR spectroscopy and theoretically by Density Functional Theory (DFT). The specific pattern of the intra and intermolecular interactions in 1,3,4-thiadiazole derivatives is described within

Development of a rapid method for the determination of antibiotic residues in honey using UPLC-ESI-MS/MS.

Kivrak I, et al.

Food Sci. Technol., 36(1), 90-96 (2016)

Coordination chemistry of sulfamethizole: crystal structures of [Cu (sulfamethizolate) 2 (py) 2 (OH 2)]? H 2 O,[M (sulfamethizolate) 2 (py) 2 (OH 2) 2][M= Co and Ni] and {Cu (sulfamethizolate) 2 (dmf) 2}?.

Borras E, et al.

Polyhedron, 19(15), 1859-1866 (2000)

Development of sulfonamide AKT PH domain inhibitors.

Ali Md Ahad et al.

Bioorganic & medicinal chemistry, 19(6), 2046-2054 (2011-03-01)

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations.

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全球贸易项目编号

货号	GTIN
S5632-25G	04061836954628
S5632-10G	04061836954611

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