Z2376
Zinquin
≥95% (HPLC), solid
别名:
2-[[2-Methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy]acetic acid, Zinquin A
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关于此项目
经验公式（希尔记法）:
C19H18N2O5S
化学文摘社编号:
分子量:
386.42
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C19H18N2O5S/c1-12-3-7-16(8-4-12)27(24,25)21-17-10-15(26-11-18(22)23)9-14-6-5-13(2)20-19(14)17/h3-10,21H,11H2,1-2H3,(H,22,23)
SMILES string
Cc1ccc(cc1)S(=O)(=O)Nc2cc(OCC(O)=O)cc3ccc(C)nc23
InChI key
CGNKOBNGEFZRQU-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
color
off-white
solubility
DMSO: soluble, methanol: soluble
functional group
carboxylic acid
storage temp.
2-8°C
Quality Level
Application
Zinquin has been used to detect intracellular zinc.
Biochem/physiol Actions
Zinquin is a membrane-permeant fluorophore. It is used to detect zinc in cells by UV fluorescence. Zinquin ethyl ester can be used to monitor the change in intracellular concentrations of Zn2+ in thymocytes and hepatocytes. The ester is excited at 368nm and emits at 490nm.
Other Notes
以游离酸或盐的形式提供
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ai Q Truong-Tran et al.
Biochemical pharmacology, 66(8), 1459-1468 (2003-10-14)
The epithelium lining the airways is a physical barrier as well as a regulator of physiological and pathological events in the respiratory system. Damage to the epithelium by oxidants released from inflammatory cells is a critical factor in the pathogenesis
Jennifer Kaltenberg et al.
European journal of immunology, 40(5), 1496-1503 (2010-03-05)
Zinc signals, i.e. a change of the intracellular concentration of free zinc ions in response to receptor stimulation, are involved in signal transduction in several immune cells. Here, the role of zinc signals in T-cell activation by IL-2 was investigated
Correlation of apoptosis with change in intracellular labile Zn(ll) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(ll)
Peter D Z, et al.
The Biochemical Journal, 296, 403-408 (1993)
Andrew B Nowakowski et al.
Inorganic chemistry, 50(20), 10124-10133 (2011-09-13)
Zinquin (ZQ) is a commonly used sensor for cellular Zn(2+) status. It has been assumed that it measures accessible Zn(2+) concentrations in the nanomolar range. Instead, this report shows a consistent pattern across seven mammalian cell and tissue types that
Chris D G and Joseph R L
Reviews in Fluorescence (2007)
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