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Merck
CN

07188

莫匹罗星锂

≥95.0% (HPLC)

别名:

9-((E)-4-{(2S,3R,4R,5S)-3,4-二羟基-5-[(2S,3S)-3-((1S,2S)-2-羟基-1-甲基-丙基)环氧乙烷基甲基]四氢吡喃-2-基}-3-甲基-丁-2-烯酰氧基)壬酸 锂盐, 假单胞菌酸A 锂盐

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关于此项目

经验公式（希尔记法）:
C26H43LiO9
化学文摘社编号:
73346-79-9
分子量:
506.56
UNSPSC Code:
51102829
PubChem Substance ID:
329748364
NACRES:
NA.85
MDL number:
MFCD11977847

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产品名称

莫匹罗星锂, ≥95.0% (HPLC)

SMILES string

[Li+].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]2CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)[C@H](O)[C@@H]2O
[Li+].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]2CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)[C@H](O)[C@@H]2O

InChI key

XFIKMPRBSORKQP-JATHGWPISA-M

InChI

1S/C26H44O9.Li/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27;/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29);/q;+1/p-1/b16-13+;/t17-,18-,19-,20-,21-,24+,25-,26-;/m0./s1

assay

≥95.0% (HPLC)

form

powder

color

white to off-white

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

Quality Level

200

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相关类别

Application

莫匹罗星锂已用于研究金黄色葡萄球菌和支原体敏感性研究中的莫匹罗星耐药性。

Other Notes

保存于密闭容器内，置于干燥通风处。置于干燥处保存。储存类别（TRGS 510）：不可燃的固体

Packaging

无底玻璃瓶。内含物装在锥底内插管中。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000462282
0000462282
0000458070
0000458070
0000405072

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Journal of medical microbiology, 47(12), 1115-1122 (1998-12-18)
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J Gilbart et al.
Antimicrobial agents and chemotherapy, 37(1), 32-38 (1993-01-01)
Mupirocin resistance in Staphylococcus aureus results from changes in the target enzyme, isoleucyl-tRNA synthetase (IRS). Twelve strains of S. aureus comprising four susceptible (MICs < or = 4 micrograms/ml), four intermediate level-resistant (MICs between 8 and 256 micrograms/ml), and four
P Kohler et al.
Infection, 41(1), 33-40 (2012-07-12)
Methicillin-resistant Staphylococcus aureus (MRSA) decolonization is a widely established, though controversial part of many MRSA controlling strategies. The aim of this study was to evaluate our decolonization success rate, identify the risk factors for decolonization failure and determine the optimal
Susan K Weir et al.
Journal of clinical microbiology, 50(10), 3283-3286 (2012-07-28)
We aimed to determine whether additional molecular and microbiological evaluations of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients newly identified as nasal carriers were useful for control strategies and whether longitudinal testing during the same or repeat hospitalization changed MRSA
S Choudhury et al.
The Journal of hospital infection, 82(1), 56-57 (2012-08-03)
High-level resistance to mupirocin in meticillin-resistant Staphylococcus aureus (MRSA) jeopardizes its role in nasal decolonization protocols. We carried out a study in 2010 to determine the prevalence of high-level mupirocin resistance in our tertiary-care hospital. The prevalence of high-level resistance
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