14699
2-Deoxy-D-ribonic acid lithium salt
≥95.0% (TLC)
别名:
2-Deoxy-D-erythro-pentonic acid lithium salt
方案
≥95.0% (TLC)
旋光性
[α]/D 12.0±2.0°, 24 hr, c = 1 in 1 M HCl
储存温度
2-8°C
SMILES字符串
OC[C@@H](O)[C@@H](O)CC(O)=O
InChI
1S/C5H10O5/c6-2-4(8)3(7)1-5(9)10/h3-4,6-8H,1-2H2,(H,9,10)/t3-,4+/m0/s1
InChI key
VBUWJOHKCBQXNU-IUYQGCFVSA-N
生化/生理作用
2-Deoxyribonic acid is the acid form of deoxyribonate, intercovertible with 2-Deoxy-ribonolactone, produced as part of bistranded lesions by DNA damaging agents, by ionizing radiation, organometallic oxidants, and is a metastable intermediate in DNA damage mediated by copper phenanthroline nucleases, and is also formed under anaerobic conditions in the presence of the radiosensitizing agent tirapazamine. It has been found in normal human biofluids.
其他说明
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Isolation of 2-deoxy-D-erythro-pentonic acid from an alkali-labile site in gamma-irradiated DNA.
M Dizdaroglu et al.
International journal of radiation biology and related studies in physics, chemistry, and medicine, 32(5), 481-483 (1977-11-01)
M Davies et al.
Acta endocrinologica, 104(2), 210-215 (1983-10-01)
Serum vitamin D metabolites, the renal tubular maximum reabsorptive rate for phosphate (TMP/GFR) nephrogenic cyclic AMP (NcAMPI, and CaE (urinary calcium excretion per litre of glomerular filtrate) were measured in 14 adults with familial hypocalciuric hypercalcaemia (FHH). The findings were
Cleavage of the intermediate hydroperoxides in the oxidation of D-glucose and D-fructose with oxygen.
Vuorinen, T.
Carbohydrate Research, 141, 319-322 (1985)
Kinetics and mechanism of the reduction of CrVI to CrIII by D-ribose and 2-deoxy-D-ribose.
Daier, V., et al.
Canadian Journal of Chemistry, 77, 57-64 (1999)
Kelly M Kroeger et al.
Biochemistry, 42(8), 2449-2455 (2003-02-26)
2-Deoxyribonolactone (3) is produced in DNA as a result of reaction with a variety of DNA damaging agents. The lesion undergoes beta-elimination to form a second metastable electrophilic product (4). In this study, DNA containing 2-deoxyribonolactone (3) and its beta-elimination
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