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Merck
CN

163M-1

CD163 (MRQ-26) Mouse Monoclonal Antibody

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
MRQ-26, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species reactivity:
human
Citations:
7
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

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biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-26, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (163M-14)
vial of 0.5 mL concentrate (163M-15)
bottle of 1.0 mL predilute (163M-17)
vial of 1.0 mL concentrate (163M-16)
bottle of 7.0 mL predilute (163M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

isotype

IgG1

control

inflamed tissue

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Quality Level

100
500

Gene Information

human ... CD163(9332)

相关类别

Analysis Note


IVD
IVD
IVD
RUO

General description

CD163, also known as scavenger receptor cysteine-rich type 1 protein M130, is an acute phase-regulated and signal-inducing transmembrane protein found exclusively on cells of monocytic origin. CD163 plays a critical role in macrophage clearance and endocytosis of hemoglobin/haptoglobin complexes. Therefore, CD163 contributes to the anti-inflammatory response and protects tissues from oxidative and inflammatory hemoglobin. Anti-CD163labels cells of monocytic-macrophage lineage, with expression in the bone marrow and histiocytic neoplasms.

Other Notes

CD163 Positive Control Slides, Product No. 163S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000484320
0000484320
0000478768
0000478768
0000484321

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Atsushi Hiraoka et al.
Pathology, research and practice, 201(5), 379-384 (2005-07-29)
CD163 is a marker of activated macrophages, and increased levels of soluble CD163 have been detected in sera obtained from patients with hepatitis. The aim of this study was to detect the expression of CD163 in the liver from patients
E Backé et al.
Journal of clinical pathology, 44(11), 936-945 (1991-11-01)
A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and
Haonan Lu et al.
Cell reports. Medicine, 4(7), 101092-101092 (2023-06-23)
Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm
Anders Etzerodt et al.
Antioxidants & redox signaling, 18(17), 2352-2363 (2012-08-21)
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages
P Högger et al.
Journal of immunology (Baltimore, Md. : 1950), 161(4), 1883-1890 (1998-08-26)
The RM3/1 Ag is a membrane glycoprotein restricted to human monocytes and macrophages that evolve in the late phase of inflammation. Peptide sequence analysis of the RM3/1 protein revealed similarity to CD163, a member of the scavenger receptor cysteine-rich family.
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