22640
奎宁 半硫酸盐 一水合物
BioReagent, suitable for fluorescence, 99.0-101.0%
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关于此项目
经验公式（希尔记法）:
C20H24N2O2 · 0.5H2O4S · H2O
化学文摘社编号:
分子量:
391.47
Beilstein:
6113937
MDL编号:
UNSPSC代码:
12352210
PubChem化学物质编号:
NACRES:
NA.32
产品线
BioReagent
质量水平
方案
99.0-101.0%
mp
~225 °C (dec.) (lit.)
荧光
λex 347 nm; λem 448 nm in 0.5 M sulfuric acid
适用性
suitable for fluorescence
抗生素抗菌谱
parasites
作用机制
enzyme | inhibits
SMILES字符串
O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
InChI
1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
InChI key
ZHNFLHYOFXQIOW-LPYZJUEESA-N
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一般描述
Quinine hemisulfate salt monohydrate is a naturally occurring well known fluorescent standard material. Quinine hemisulfate salt monohydrate or QSM has a fluorescence lifetime between 1.0 to 3.0 ns.
应用
Quinine hemisulfate salt monohydrate is used for indirect photometric detection of polyamines in biological samples. It is suitable for studying metabolism of bio crystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
生化/生理作用
钾通道阻滞剂。抗疟疾
钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂；最初从南美树木的金鸡纳科中分离出来的生物碱。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Elaine B Bohórquez et al.
Malaria journal, 11, 350-350 (2012-10-24)
The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved. The Plasmodium falciparum multidrug
S D Pack et al.
Optics letters, 23(15), 1215-1217 (2007-12-19)
We report on a novel laser-induced fluorescence triple-integration method (LIFTIME) that is capable of making rapid, continuous fluorescence lifetime measurements by a unique photon-counting technique. The LIFTIME has been convolved with picosecond time-resolved laser-induced fluorescence, which employs a high-repetition-rate mode-locked
Y Ma et al.
Journal of chromatography, 608(1-2), 93-96 (1992-09-11)
A rapid separation of polyamines and some related amino acids in cultured tumor cells by high-performance capillary zone electrophoresis with indirect photometric detection is demonstrated. 60 cm x 75 microns I.D. fused-silica capillary was used for the separation and quinine
F G Welsch et al.
ACS combinatorial science, 13(5), 518-529 (2011-08-13)
We describe here the results of a high throughput screening study for direct methanol fuel cell (DMFC) anode catalysts consisting of new elemental combinations with an optical high-throughput screening method, which allows the quantitative evaluation of the electrochemical activity of
Yuting Bai et al.
Nanoscale research letters, 13(1), 287-287 (2018-09-19)
Carbon dots (CDs) are a member of fluorescent carbon nanomaterials that are widely applied in bioimaging, photothermal therapy (PTT), and biosensors for its tunable fluorescence, photothermal conversion property, and excellent biocompatibility. Surface passivation and doping especially the doping of N
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