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经验公式(希尔记法):
C20H24N2O2 · 0.5H2O4S · H2O
化学文摘社编号:
分子量:
391.47
UNSPSC Code:
12352210
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6113937
InChI
1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
SMILES string
O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
InChI key
ZHNFLHYOFXQIOW-LPYZJUEESA-N
product line
BioReagent
assay
99.0-101.0%
mp
~225 °C (dec.) (lit.)
fluorescence
λex 347 nm; λem 448 nm in 0.5 M sulfuric acid
suitability
suitable for fluorescence
antibiotic activity spectrum
parasites
mode of action
enzyme | inhibits
Quality Level
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General description
Quinine hemisulfate salt monohydrate is a naturally occurring well known fluorescent standard material. Quinine hemisulfate salt monohydrate or QSM has a fluorescence lifetime between 1.0 to 3.0 ns.
Application
Quinine hemisulfate salt monohydrate is used for indirect photometric detection of polyamines in biological samples. It is suitable for studying metabolism of bio crystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Biochem/physiol Actions
钾通道阻滞剂。抗疟疾
钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂;最初从南美树木的金鸡纳科中分离出来的生物碱。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Elaine B Bohórquez et al.
Malaria journal, 11, 350-350 (2012-10-24)
The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved. The Plasmodium falciparum multidrug
Y Ma et al.
Journal of chromatography, 608(1-2), 93-96 (1992-09-11)
A rapid separation of polyamines and some related amino acids in cultured tumor cells by high-performance capillary zone electrophoresis with indirect photometric detection is demonstrated. 60 cm x 75 microns I.D. fused-silica capillary was used for the separation and quinine
S D Pack et al.
Optics letters, 23(15), 1215-1217 (2007-12-19)
We report on a novel laser-induced fluorescence triple-integration method (LIFTIME) that is capable of making rapid, continuous fluorescence lifetime measurements by a unique photon-counting technique. The LIFTIME has been convolved with picosecond time-resolved laser-induced fluorescence, which employs a high-repetition-rate mode-locked
Kira Behm et al.
Dalton transactions (Cambridge, England : 2003), 46(33), 10867-10875 (2017-08-02)
The synthesis, characterization, and fluorescence spectroscopy of E(C
Marta Pokrzywnicka et al.
Talanta, 82(1), 422-425 (2010-08-06)
In this paper a concept of very simple measurement system dedicated for simultaneous photometric and fluorometric detection is presented. Only three ordinary unmodified light emitting diodes (LEDs) can be applied in this analytical device: one of them is used in
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