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30020

D-环丝氨酸

Name: <SC>D</SC>-环丝氨酸
Brand: SIGMA

别名:

(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮

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关于此项目

经验公式（希尔记法）:

C₃H₆N₂O₂

化学文摘社编号:

68-41-7

分子量:

102.09

UNSPSC Code:

51102829

NACRES:

NA.85

PubChem Substance ID:

57648401

EC Number:

200-688-4

Beilstein/REAXYS Number:

80798

MDL number:

MFCD00005353

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biological source

synthetic

Quality Level

100

form

powder

potency

≥900 μg per mg

color

white to off-white

mp

147 °C (dec.) (lit.)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

cell wall synthesis | interferes

storage temp.

−20°C

SMILES string

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI key

DYDCUQKUCUHJBH-UWTATZPHSA-N

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General description

Chemical structure: amino acid derivatives

Application

D-Cycloserine acts as inhibitor of various enzymes.

Biochem/physiol Actions

作用方式：抑制细胞壁生物合成（D-Ala 肽键形成）。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂；抗革兰氏阴性细菌的抗生素。
干预方式：D-Ala转运干预。

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.

Packaging

1g, 5g, 25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

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分析证书(COA)

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D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens.

Mary M Torregrossa et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(31), 10526-10533 (2010-08-06)

Extinction therapy has been proposed as a method to reduce the motivational impact of drug-associated cues to prevent relapse. Cue extinction therapy, however, takes place in a novel context (e.g., treatment facility), and is unlikely to be effective due to

D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury.

Rami Yaka et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21(9), 2033-2041 (2007-03-14)

Traumatic brain injury triggers a massive glutamate efflux, activation of NMDA receptor channels, and cell death. Recently, we reported that NMDA receptors in mice are down-regulated from hours to days following closed head injury (CHI), and treatment with NMDA improved

D-cycloserine augmentation of cognitive behavioral therapy for anxiety disorders: an update.

Stefan G Hofmann et al.

Current psychiatry reports, 17(1), 532-532 (2014-11-22)

Although cognitive behavioral therapy (CBT) is a generally effective treatment for treating anxiety disorders, there is clearly still room for further improvements. Recent advances in neuroscience of extinction learning led to novel clinical strategies to augment exposure-based treatments with d-cycloserine

M.K. Jain

Handbook of Enzyme Inhibitors, 112-112 (1982)

D-cycloserine enhances generalization of fear extinction in children.

Simon P Byrne et al.

Depression and anxiety, 32(6), 408-414 (2015-03-17)

For exposure therapy to be successful, it is essential that fear extinction learning extends beyond the treatment setting. D-cycloserine (DCS) may facilitate treatment gains by increasing generalization of extinction learning, however, its effects have not been tested in children. We

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全球贸易项目编号

货号	GTIN
30020-25G	04061835541225
30020-5G	04061835517886
30020-1G	04061835541218

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