30432
丹酰尸胺
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
别名:
N-（5-氨基戊基）-5-二甲基氨基萘-1-磺酰胺, N-（二甲基氨基萘磺酰）-1，5-戊二胺, 丹酰尸胺
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关于此项目
经验公式（希尔记法）:
C17H25N3O2S
化学文摘社编号:
分子量:
335.46
Beilstein:
2951070
EC 号:
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.32
产品线
BioReagent
质量水平
方案
≥99.0% (HPLC)
mp
137-140 °C
荧光
λex 335 nm; λem 518 nm in methanol
λex 338 nm; λem 500 nm (Reaction product)
适用性
suitable for fluorescence
储存温度
−20°C
SMILES字符串
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
InChI
1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key
MLEBFEHOJICQQS-UHFFFAOYSA-N
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应用
丹酰戊二胺（MDC），一种自荧光染料，被用来监测细胞自我吞噬。 因为离子捕获和特异性膜脂互作，MDC在自噬泡中累积。
生化/生理作用
纤维蛋白稳定因子抑制剂；表皮生长因子（EGF）内化抑制剂酰胺顺反异构转化酶分析荧光底物。
自发荧光染料丹酰尸胺或单丹磺酰尸胺（MDC）通常用于监测自噬。 由于离子捕获和与膜脂质的特异性相互作用的组合，单丹磺酰尸胺优先在自噬泡中积累。
包装
无底玻璃瓶。内容物在插入式融锥内。
空气敏感，在惰性气体下处理
其他说明
在甲醇（10 mg/mL）中测试丹酰尸胺的溶解度。据报道，丹酰尸胺可溶于 DMSO 和乙酸。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Elevating the intracellular concentration of Ca2+ ions in human erythrocytes leads to the formation of membrane-associated polymers, composed of skeletal and cytoplasmic proteins. The anion transporter band 3 serves as a membrane anchor for this N epsilon-(gamma-glutamyl)lysine cross-linked polymer. The
Fibrin-stabilizing factor inhibitors. 3. Sulphonamides related to monodansylcadaverine.
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The binding and internalization of 125I-epidermal growth factor (125I-EGF) was studied in cultures of BALB 3T3 cells using a novel method that involved removal of cell-surface hormone by treatment with acetic acid under conditions that did not remove internalized hormone.
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Androgen receptor has a critical role in prostate cancer development and progression. Cell death via autophagy may also contribute to prostate cancer progression. We determined the role and regulatory effects of androgen receptor on the autophagy process of prostate cancer
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