30957
2-Deoxy-D-ribono-1,4-lactone
≥95% (GC)
别名:
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one, 2-Deoxy-D-ribonic acid γ-lactone
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关于此项目
经验公式（希尔记法）:
C5H8O4
化学文摘社编号:
分子量:
132.11
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
81260
InChI
1S/C5H8O4/c6-2-4-3(7)1-5(8)9-4/h3-4,6-7H,1-2H2/t3-,4+/m0/s1
SMILES string
O[C@H]1CC(O[C@@H]1CO)=O
InChI key
YIXDEYPPAGPYDP-IUYQGCFVSA-N
assay
≥95% (GC)
optical activity
[α]/D 19.0±2.5°, c = 1 in H2O
suitability
conforms to structure for Proton NMR spectrum
storage temp.
−20°C
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Brian C Bales et al.
Nucleic acids research, 33(16), 5371-5379 (2005-09-28)
Copper-phenanthroline complexes oxidatively damage and cleave nucleic acids. Copper bis-phenanthroline and copper complexes of mono- and bis-phenanthroline conjugates are used as research tools for studying nucleic acid structure and binding interactions. The mechanism of DNA oxidation and cleavage by these
Yoann Roupioz et al.
Journal of the American Chemical Society, 124(31), 9129-9135 (2002-08-01)
Deoxyribonolactone in DNA is an oxidized abasic site damage that is produced by a variety of physical and chemical agents such as gamma-irradiation and ene-diyne antibiotics. The extent and biological significance of the lesion are poorly documented due to the
Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.
Liang Xue et al.
Angewandte Chemie (International ed. in English), 46(4), 561-564 (2006-12-13)
Haidong Huang et al.
Biochemistry, 48(33), 7833-7841 (2009-07-22)
Tandem lesions are comprised of two contiguously damaged nucleotides. Tandem lesions make up the major family of reaction products generated from a pyrimidine nucleobase radical, which are formed in large amounts by ionizing radiation. One of these tandem lesions contains
Yana Cen et al.
The Journal of organic chemistry, 74(16), 5779-5789 (2009-12-05)
Methods to construct 2'-deoxy-2'-fluoro nucleosides have undergone limited improvement in the last 20 years in spite of the substantially increased value of these compounds as pharmaceuticals and as tools for studying biological processes. We herein describe a consolidated approach to
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