30957
2-Deoxy-D-ribono-1,4-lactone
≥95% (GC)
别名:
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one, 2-Deoxy-D-ribonic acid γ-lactone
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关于此项目
经验公式（希尔记法）:
C5H8O4
化学文摘社编号:
分子量:
132.11
Beilstein:
81260
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.25
方案
≥95% (GC)
旋光性
[α]/D 19.0±2.5°, c = 1 in H2O
适用性
conforms to structure for Proton NMR spectrum
储存温度
−20°C
SMILES字符串
O[C@H]1CC(O[C@@H]1CO)=O
InChI
1S/C5H8O4/c6-2-4-3(7)1-5(8)9-4/h3-4,6-7H,1-2H2/t3-,4+/m0/s1
InChI key
YIXDEYPPAGPYDP-IUYQGCFVSA-N
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Bruce Demple et al.
DNA repair, 4(12), 1442-1449 (2005-10-04)
Many oxidative DNA lesions are handled well by base excision repair (BER), but some types may be problematic. Recent work indicates that 2-deoxyribonolactone (dL) is such a lesion by forming stable, covalent cross-links between the abasic residue and DNA repair
Marc M Greenberg
Organic & biomolecular chemistry, 5(1), 18-30 (2006-12-14)
DNA damage is a double-edged sword. The modifications produced in the biopolymer are associated with aging, and give rise to a variety of diseases, including cancer. DNA is also the target of anti-tumor agents and the most generally used nonsurgical
2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release.
Marina Roginskaya et al.
Angewandte Chemie (International ed. in English), 44(38), 6210-6213 (2005-09-02)
Haidong Huang et al.
The Journal of organic chemistry, 73(7), 2695-2703 (2008-03-08)
DNA damage results in the formation of abasic sites from the formal hydrolysis of the glycosidic bond (AP) and several oxidized abasic lesions. Previous studies on AP sites revealed that DNA polymerases preferentially incorporated dA opposite them in approximately 80%
Haidong Huang et al.
Journal of the American Chemical Society, 130(19), 6080-6081 (2008-04-17)
The ability of DNA polymerases to maintain the integrity of the genome even after it has been structurally altered is vital. There is considerable interest in determining the structural properties of the DNA template that polymerases recognize when determining which
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