biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (338A-74)
vial of 0.5 mL concentrate (338A-75)
bottle of 1.0 mL predilute (338A-77)
vial of 1.0 mL concentrate (338A-76)
bottle of 7.0 mL predilute (338A-78)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
control
thymus
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... DNTT(1791)
Analysis Note
 IVD |  IVD |  IVD |  RUO |
General description
TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerasethat adds nucleotides randomly to single-stranded DNA. This randomization plays a role inacquired immunity by increasing antigen receptor diversity and aiding in the generation ofimmunoglobulins and T-cell antigen receptors. TdT immunoreactivity is observed mainly in the thymus. Anti-TdT is often used to visualize lymphoblastic lymphomas and has also beenobserved in some cases of acute myeloid leukemia.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
A Practical Approach to Diagnosis, 312-316 (1990)
R C Mathewson et al.
Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 17(6), 835-844 (1997-11-14)
In the differential diagnosis of small round cell tumors (SRCTs), terminal deoxynucleotidyl transferase (TdT) is often used as a marker for lymphoblastic lymphomas and leukemias. However, the specificity of TdT using the avidin-biotin-immunoperoxidase (ABC) method is not well documented. To
M Ozdemirli et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(11), 1175-1182 (2001-11-14)
We encountered a child with an intraosseous small round cell tumor that was negative for LCA, CD20 (L26), and CD3 and positive for vimentin, CD99 (MIC-2), and periodic acid-Schiff. The tumor exhibited rosette-like formations. This case was initially interpreted as
Ewing sarcoma vs lymphoblastic leukemia.
S Hirschl
American journal of clinical pathology, 115(6), 933-934 (2001-06-08)
R A Soslow et al.
Human pathology, 28(10), 1158-1165 (1997-10-29)
We propose that 12E7 (CD99) expression, along with TdT, bcl-2, and CD34 reactivity in lymphoblastic lymphoma (LyL)/acute lymphoblastic leukemia (ALL), distinguishes this group of neoplasms from small noncleaved cell lymphomas (SNCLs) in both pediatric and adult patients, thereby narrowing the
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