生物来源
rabbit
偶联物
unconjugated
抗体形式
culture supernatant
抗体产品类型
primary antibodies
克隆
EP190, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (358R-14)
vial of 0.1 mL concentrate Research Use Only (358R-14-RUO)
vial of 0.5 mL concentrate (358R-15)
vial of 1.0 mL concentrate (358R-16)
vial of 1.0 mL concentrate Research Use Only (358R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (358R-17)
vial of 7.0 mL pre-dilute ready-to-use (358R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
同位素/亚型
IgG
控制
diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil
运输
wet ice
储存温度
2-8°C
可视化
cytoplasmic, nuclear
基因信息
human ... PWWP3A(84939)
一般描述
Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma. However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive. MUM1 is also expressed in plasma cell myeloma.
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
分析说明
 IVD |  IVD |  IVD |  RUO |
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T Yamagata et al.
Molecular and cellular biology, 16(4), 1283-1294 (1996-04-01)
We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely
W Kempf et al.
The British journal of dermatology, 158(6), 1280-1287 (2008-04-16)
Primary cutaneous CD30+ lymphoproliferative disorders include lymphomatoid papulosis (LyP) and primary cutaneous CD30+ anaplastic large T-cell lymphoma (ALCL). Because of overlapping histological features, it is impossible to distinguish ALCL from LyP on histological grounds. MUM1 (Multiple Myeloma oncogene 1) is
Gabriela Gualco et al.
Human pathology, 40(4), 565-571 (2009-01-16)
Burkitt lymphoma is a highly aggressive non-Hodgkin lymphoma with endemic, sporadic, and immunodeficiency-associated clinical variants composed of monomorphic medium-sized B cells with a high proliferation rate and a translocation involving the C-MYC locus. Classically, the immunophenotype of Burkitt lymphoma has
Christine P Hans et al.
Blood, 103(1), 275-282 (2003-09-25)
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like (GCB), activated B-cell-like (ABC), and type 3 gene expression profiles using a cDNA microarray. Tissue microarray (TMA) blocks were created from 152 cases of
Uma Sundram et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 16(8), 802-810 (2003-08-16)
The diagnosis of malignant melanoma remains one of the most difficult to render in surgical pathology, partially because of its extreme histologic variability. Limits in the sensitivity and/or specificity of the currently available melanocytic markers such as anti-S100, HMB45, and
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