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Merck
CN

367M-1

Sigma-Aldrich

IgG4 (MRQ-44) Mouse Monoclonal Antibody

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

MRQ-44, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (367M-14)
vial of 0.5 mL concentrate (367M-15)
bottle of 1.0 mL predilute (367M-17)
vial of 1.0 mL concentrate (367M-16)
bottle of 7.0 mL predilute (367M-18)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同位素/亚型

IgG1κ

控制

tonsil

运输

wet ice

储存温度

2-8°C

可视化

cytoplasmic

一般描述

The igG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas, bile duct, gall bladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues.

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

分析说明


IVD

IVD

IVD

RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
IgG4 Positive Control Slides, Product No. 367S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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法规信息

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分析证书(COA)

Lot/Batch Number

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Sudhir Dhobale et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 15(7), 354-357 (2009-12-17)
Great attention has been drawn toward the recently defined IgG4 related sclerosing disease, an entity incorporating autoimmune pancreatitis and other organ involvements, hypergammaglobulinemia and deposition of IgG4 in affected tissues. We demonstrate an index case of this disease with multiple
Noriyuki Sakata et al.
The American journal of surgical pathology, 32(4), 553-559 (2008-02-28)
Inflammatory abdominal aortic aneurysm (IAA) is associated with autoimmune disease. However, the precise mechanism of IAA remains unclear. There is increasing evidence that IgG4 is involved in the autoimmune mechanism of various idiopathic sclerosing lesions, including sclerosing pancreatitis and retroperitoneal
Wah Cheuk et al.
The American journal of surgical pathology, 33(7), 1058-1064 (2009-04-23)
Immunoglobulin G (IgG)4-related sclerosing disease is a recently described syndrome characterized by mass-forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, elevated serum IgG4 titer, increased tissue IgG4 plasma cells, and favorable clinical outcome. We describe
Yaqiong Li et al.
Pathology international, 59(9), 636-641 (2009-08-29)
IgG4-related sclerosing disease has been recently recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration by many IgG4-positive plasma cells. Similar histopathological features have often been noted in the fibrous
Terumi Kamisawa et al.
World journal of gastroenterology, 15(19), 2357-2360 (2009-05-20)
To clarify the characteristic features of biliary lesions in patients with autoimmune pancreatitis (AIP) and compare them with those of primary sclerosing cholangitis (PSC). The clinicopathological characteristics of 34 patients with sclerosing cholangitis (SC) associated with AIP were compared with

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