生物来源
rabbit
偶联物
unconjugated
抗体形式
Ig fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
表单
buffered aqueous solution
种属反应性
human
包装
vial of 0.1 mL concentrate (369A-14)
vial of 0.5 mL concentrate (369A-15)
bottle of 1.0 mL predilute (369A-17)
vial of 1.0 mL concentrate (369A-16)
bottle of 7.0 mL predilute (369A-18)
制造商/商品名称
Cell Marque®
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
控制
tonsil
运输
wet ice
储存温度
2-8°C
可视化
nuclear
基因信息
human ... H3C1(8350)
相关类别
一般描述
Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. Therefore, PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in the diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
分析说明
 IVD |  IVD |  IVD |  RUO |
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Phosphohistone H3 (PHH3) Positive Control Slides, Product No. 369S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
法律信息
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yoo-Jin Kim et al.
American journal of clinical pathology, 128(1), 118-125 (2007-06-21)
Mitotic activity is one of the most reliable prognostic factors in meningiomas. The identification of mitotic figures (MFs) and the areas of highest mitotic activity in H&E-stained slides is a tedious and subjective task. Therefore, we compared the results from
Howard Colman et al.
The American journal of surgical pathology, 30(5), 657-664 (2006-05-16)
Distinguishing between grade II and grade III diffuse astrocytomas is important both for prognosis and for treatment decision-making. However, current methods for distinguishing between grades based on proliferative potential are suboptimal, making identification of clear cutoffs difficult. In this study
Sayantani Goswami et al.
Journal of cellular physiology, 236(12), 8148-8159 (2021-07-01)
A number of studies have examined the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) on intestinal inflammation driven by immune cells, while little information is currently available about its impact on inflammation caused by intestinal epithelial cell (IEC) defects. Mice
Michel R Nasr et al.
The American Journal of dermatopathology, 30(2), 117-122 (2008-03-25)
Differentiating malignant melanoma from benign melanocytic lesions can be challenging. We undertook this study to evaluate the use of the immunohistochemical mitosis marker phospho-Histone H3 (pHH3) and the proliferation markers Ki-67 and survivin in separating malignant melanoma from benign nevi.
Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells.
L R Gurley et al.
European journal of biochemistry, 84(1), 1-15 (1978-03-01)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持