42491
1,2-Dioleoyl-sn-glycero-3-phosphoric acid sodium salt
≥98.0% (TLC)
别名:
3-sn-Phosphatidic acid, 1,2-dioleoyl sodium salt, L-β,γ-Dioleoyl-α-phosphatidic acid sodium salt, DOPA
方案
≥98.0% (TLC)
溶解性
chloroform: 20 mg/mL, clear, colorless
运输
wet ice
储存温度
−20°C
SMILES字符串
[Na+].[Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](COP([O-])([O-])=O)OC(=O)CCCCCCC\C=C/CCCCCCCC
生化/生理作用
1,2-Dioleoyl-sn-glycero-3-phosphoric acid is a phosphatidic acid. Phospholipids, major membrane lipids, are derived from phosphatidic acid .
1,2-Dioleoyl-sn-glycero-3-phosphoric acid regulates phospholipid metabolic genes in yeast by binding to transcriptional factor, Opi1. This binding is regulated by a rapid decrease in pH in response to glucose starvation. 1,2-Dioleoyl-sn-glycero-3-phosphoric acid acts as intracellular pH biosensor, coupling membrane biogenesis to nutrient availability .
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Lipids of Physiologic Significance
Botham, K. M.
Harper′s Illustrated Biochemistry Edition: 28th, 28th, 124-124 (2009)
Barry P Young et al.
Science (New York, N.Y.), 329(5995), 1085-1088 (2010-08-28)
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid
Fernando J Barreyro et al.
The Journal of biological chemistry, 282(37), 27141-27154 (2007-07-13)
Hepatocyte lipoapoptosis, a critical feature of nonalcoholic steatohepatitis, can be replicated in vitro by incubating hepatocytes with saturated free fatty acids (FFA). These toxic FFA induce Bim expression, which is requisite for their cytotoxicity. Because the FoxO3a transcription factor has
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