42491
1,2-Dioleoyl-sn-glycero-3-phosphoric acid sodium salt
≥98.0% (TLC)
别名:
3-sn-Phosphatidic acid, 1,2-dioleoyl sodium salt, L-β,γ-Dioleoyl-α-phosphatidic acid sodium salt, DOPA
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关于此项目
经验公式（希尔记法）:
C39H71Na2O8P
化学文摘社编号:
分子量:
744.93
UNSPSC Code:
12352211
PubChem Substance ID:
Beilstein/REAXYS Number:
3884561
SMILES string
[Na+].[Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](COP([O-])([O-])=O)OC(=O)CCCCCCC\C=C/CCCCCCCC
assay
≥98.0% (TLC)
solubility
chloroform: 20 mg/mL, clear, colorless
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
1,2-Dioleoyl-sn-glycero-3-phosphoric acid is a phosphatidic acid. Phospholipids, major membrane lipids, are derived from phosphatidic acid .
1,2-Dioleoyl-sn-glycero-3-phosphoric acid regulates phospholipid metabolic genes in yeast by binding to transcriptional factor, Opi1. This binding is regulated by a rapid decrease in pH in response to glucose starvation. 1,2-Dioleoyl-sn-glycero-3-phosphoric acid acts as intracellular pH biosensor, coupling membrane biogenesis to nutrient availability .
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Barry P Young et al.
Science (New York, N.Y.), 329(5995), 1085-1088 (2010-08-28)
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid
Lipids of Physiologic Significance
Botham, K. M.
Harper′s Illustrated Biochemistry Edition: 28th, 28th, 124-124 (2009)
Fernando J Barreyro et al.
The Journal of biological chemistry, 282(37), 27141-27154 (2007-07-13)
Hepatocyte lipoapoptosis, a critical feature of nonalcoholic steatohepatitis, can be replicated in vitro by incubating hepatocytes with saturated free fatty acids (FFA). These toxic FFA induce Bim expression, which is requisite for their cytotoxicity. Because the FoxO3a transcription factor has
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