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Merck
CN

479M-9

Sigma-Aldrich

MDM2 (IF2) Mouse Monoclonal Antibody

别名:

Mouse double minute protein 2

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UNSPSC代码:
12352203

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生物来源

mouse

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

IF2, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

表单

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (479M-94)
vial of 0.1 mL concentrate Research Use Only (479M-94-RUO)
vial of 0.5 mL concentrate (479M-95)
vial of 1.0 mL concentrate (479M-96)
vial of 1.0 mL concentrate Research Use Only (479M-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (479M-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (479M-97)
vial of 7.0 mL pre-dilute ready-to-use (479M-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (479M-98-RUO)

制造商/商品名称

Cell Marque®

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同位素/亚型

IgG

控制

dedifferentiated liposarcoma, well-differentiated liposarcoma

运输

wet ice

储存温度

2-8°C

可视化

nuclear

相关类别

一般描述

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.1 MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.2,4

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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分析说明

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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分析证书(COA)

Lot/Batch Number
0000495937
0000495937
0000491205
0000491205
0000223383

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A Arici et al.
Indian journal of cancer, 50(3), 164-169 (2013-09-26)
Liposarcomas are among the most common soft tissue sarcomas in adulthood. The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of
Stanislava Uhrinova et al.
Journal of molecular biology, 350(3), 587-598 (2005-06-15)
Critical to the inhibitory action of the oncogene product, MDM2, on the tumour suppressor, p53, is association of the N-terminal domain of MDM2 (MDM2N) with the transactivation domain of p53. The structure of MDM2N was previously solved with a p53-derived
Patrick L Ware et al.
American journal of clinical pathology, 141(3), 334-341 (2014-02-12)
MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. Forty-six cases of liposarcoma in various sites
Matthieu Bui Nguyen Binh et al.
American journal of clinical pathology, 125(5), 693-697 (2006-05-19)
MDM2 and CDK4 immunostaining can be useful adjuncts in diagnosing liposarcoma among soft tissue neoplasms. We examined the reproducibility of MDM2 and CDK4 staining between 2 laboratories and between tissue microarrays and whole tissue sections. Sixty-two soft tissue tumors were
J Momand et al.
Nucleic acids research, 26(15), 3453-3459 (1998-07-22)
The p53 tumor suppressor gene is inactivated in human tumors by several distinct mechanisms. The best characterized inactivation mechanisms are: (i) gene mutation; (ii) p53 protein association with viral proteins; (iii) p53 protein association with the MDM2 cellular oncoprotein. The
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