Merck
CN

50200

Sigma-Aldrich

双甘肽

BioXtra, ≥99.0% (NT)

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别名:
二甘氨酸, 甘氨酰-甘氨酸
线性分子式:
NH2CH2CONHCH2COOH
CAS号:
分子量:
132.12
Beilstein:
1765223
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

产品线

BioXtra

质量水平

检测方案

≥99.0% (NT)

形式

powder

technique(s)

ligand binding assay: suitable

灼烧残渣

≤0.1% (as SO4)

缺失

≤1% loss on drying, 110 °C

颜色

white

useful pH range

7.5-8.9

pKa (25 °C)

8.2

mp

220-240 °C (dec.)

溶解性

H2O: 1 M at 20 °C, clear, colorless

痕量阴离子

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

痕量阳离子

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

NCC(=O)NCC(O)=O

InChI

1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)

InChI key

YMAWOPBAYDPSLA-UHFFFAOYSA-N

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生化/生理作用

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Glycine and diglycine as possible catalytic factors in the prebiotic evolution of peptides.
Plankensteiner K
Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life, 32(3), 225-236 (2002)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Lasse Jenner et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3812-3816 (2013-02-23)
Here we present an X-ray crystallography structure of the clinically relevant tigecycline antibiotic bound to the 70S ribosome. Our structural and biochemical analysis indicate that the enhanced potency of tigecycline results from a stacking interaction with nucleobase C1054 within the
Francis Impens et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(34), 12432-12437 (2014-08-13)
SUMOylation is an essential ubiquitin-like modification involved in important biological processes in eukaryotic cells. Identification of small ubiquitin-related modifier (SUMO)-conjugated residues in proteins is critical for understanding the role of SUMOylation but remains experimentally challenging. We have set up a
Woong Kim et al.
Molecular cell, 44(2), 325-340 (2011-09-13)
Despite the diverse biological pathways known to be regulated by ubiquitylation, global identification of substrates that are targeted for ubiquitylation has remained a challenge. To globally characterize the human ubiquitin-modified proteome (ubiquitinome), we utilized a monoclonal antibody that recognizes diglycine

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