51063
Obidoxime chloride
≥95.0% (HPLC)
别名:
1,1′-(Oxydimethylene)bis(pyridinium-4-carbaldoxime) dichloride, Bis(4-formylpyridiniomethyl) ether dioxime, Toxogonin
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关于此项目
经验公式（希尔记法）:
C14H16Cl2N4O3
化学文摘社编号:
分子量:
359.21
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
204-059-5
Beilstein/REAXYS Number:
4117377
MDL number:
InChI key
ZIFJVJZWVSPZLE-UHFFFAOYSA-N
InChI
1S/C14H14N4O3.2ClH/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20;;/h1-10H,11-12H2;2*1H
SMILES string
[Cl-].[Cl-].O\N=C\c1cc[n+](COC[n+]2ccc(cc2)\C=N\O)cc1
assay
≥95.0% (HPLC)
form
powder or crystals
Quality Level
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General description
active agent in Toxogonin
Biochem/physiol Actions
Antidote for organophosphate nerve agent poisoning
Antidote for organophosphate nerve agent poisoning, but, as with other oxime agents, not full spectrum. Obidoxime fails primarily to reactivate acetylcholinesterase that has been inhibited with cyclosarin.
Legal Information
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Jürgen Kufleitner et al.
Journal of microencapsulation, 27(7), 594-601 (2010-10-07)
Intoxication with organophosphorous nerve agents such as paraoxon requires immediate administration of antidotes such as oximes. However, the oximes lack sufficient activity in the central nervous system as they are unable to rapidly penetrate the blood-brain barrier (BBB) in therapeutically
Franz Worek et al.
Toxicology letters, 200(1-2), 19-23 (2010-10-26)
Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. These findings provoked the present in vitro study which was designed to determine the
Yossi Rosman et al.
Journal of applied toxicology : JAT, 32(6), 409-416 (2011-08-24)
Organophosphate intoxication induces neural toxicity as demonstrated in histological analysis of poisoned animals. Diffusion-weighted magnetic resonance imaging (DWMRI) enables early noninvasive characterization of biological tissues based on their water diffusion characteristics. Our objectives were to study the application of MRI
Marloes J A Joosen et al.
Chemico-biological interactions, 188(1), 255-263 (2010-07-06)
The nerve agent VX is most likely to enter the body via liquid contamination of the skin. After percutaneous exposure, the slow uptake into the blood, and its slow elimination result in toxic levels in plasma for a period of
Guillaume Mercey et al.
Chemical communications (Cambridge, England), 47(18), 5295-5297 (2011-04-01)
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as
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