52442
红曲色素
≥97.0% (HPLC)
别名:
单子叶黄素, （3,3a,9a）-3-己酰基-9a-甲基-6-（（）-丙烯基）3a,4,8,9a-四氢-3氢-呋喃并[3,2-g]异染色质-2,9-二酮, （3,3a,9a）-3a,4,8,9a-四氢-9a-甲基-3-（1-氧代己基）-6-（1E）-1-丙烯基-2氢-呋喃[3,2-g][2]苯并吡喃-2,9（3氢）-二酮
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关于此项目
经验公式（希尔记法）:
C21H26O5
化学文摘社编号:
分子量:
358.43
Beilstein:
51355
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.47
方案
≥97.0% (HPLC)
表单
solid
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(\C=C\C)=C3)C(=O)[C@]2(C)OC1=O
InChI
1S/C21H26O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16,18H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,18+,21-/m1/s1
InChI key
XXKNHBAFFJINCK-RVEJDSBJSA-N
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一般描述
红曲霉素是红霉米中发现的主要黄色色素之一。它在结构上类似于安卡黄素。
应用
红曲霉素已被用于治疗4T1乳腺癌细胞和测试其对癌细胞失巢凋亡和生长抑制的效果。
生化/生理作用
红曲色素是红曲-发酵米（红霉米）提取物中的氮杂类色素之一。它是针对化学或紫外线引发的佛波醇促进的小鼠皮肤肿瘤测量的致癌作用的有效抑制剂。
红曲霉素(MS)发挥抗糖尿病和抗氧化特性，并分别在糖尿病大鼠和 秀丽隐杆线虫中提供高血糖控制、组织保护和耐热性。它还显示出抗肿瘤活性并抑制阿尔茨海默′病相关的 tau蛋白聚集。红曲霉素可上调高血脂仓鼠模型高密度脂蛋白胆固醇（HDL-C）水平并有降血脂性。它还可能具有保肝作用。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Malignant melanoma.
World journal of surgery, 16(2), 155-286 (1992-03-01)
S L Gartner et al.
Thymus, 19(2), 117-126 (1992-03-01)
We examined the effect of various carbohydrates on the proliferative response of murine thymocytes to cytokines. The monosaccharide, D-mannose (4-10 mM), significantly inhibited thymocyte proliferation induced by recombinant interleukin-1 (rIL-1). Mannose also inhibited the proliferation response to native, human IL-1.
Qiuyu Lin et al.
Neuroreport, 31(9), 637-643 (2020-05-20)
Increasing evidence verified that oxidative stress and neuroinflammatory response exacerbates motor deficits and increases neuronal loss in several rodent models of Parkinson's disease. In the present study, we explore the neuroprotective effects of monascin in a rotenone-induced Parkinson's disease model
Yeu-Ching Shi et al.
Free radical biology & medicine, 52(1), 109-117 (2011-11-02)
Monascin is a major yellow compound from red mold dioscorea. We investigated monascin to test whether this compound acts as an antidiabetic and antioxidative stress agent in diabetic rats and Caenorhabditis elegans. The mechanisms by which monascin exerts its action
Chun-Lin Lee et al.
Journal of agricultural and food chemistry, 58(16), 9013-9019 (2010-07-30)
Monascus-fermented red mold dioscorea (RMD) has been proven to possess greater hypolipidemic effect than red mold rice (RMR) even though they include equal levels of cholesterol-lowering agent monacolin K. However, higher concentrations of yellow pigments (monascin and ankaflavin) were found
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