53467
2,3-二油氧基-1-（二甲氨基）丙烷
≥98.0% (TLC)
别名:
1,2-二油氧基-3-（二甲氨基）丙烷, N,N-二甲基-2,3-双[(9Z)-9-十八碳烯-1-基氧基]-1-丙胺, DODMA
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关于此项目
经验公式（希尔记法）:
C41H81NO2
CAS Number:
分子量:
620.09
Beilstein:
10139013
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.85
生物来源
synthetic
质量水平
方案
≥98.0% (TLC)
表单
liquid
官能团
amine
ether
脂质类型
cationic lipids
储存温度
−20°C
SMILES字符串
CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC
InChI
1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-
InChI key
GLGLUQVVDHRLQK-WRBBJXAJSA-N
包装
无底玻璃瓶。内含物装在锥底内插管中。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids.
Heyes, J., et al.
J. Controlled Release, 107, 276-287 (2005)
Lloyd B Jeffs et al.
Pharmaceutical research, 22(3), 362-372 (2005-04-20)
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution
Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery.
Yujing Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 371-381 (2016-10-18)
Microfluidic systems can accelerate clinical translation of nanoparticles due to their ability to generate nanoparticles in a well-controlled and reproducible manner. In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs)
Adam Judge et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(2), 328-337 (2005-11-09)
The systemic application of nucleic acid drugs requires delivery systems that overcome the poor pharmacokinetics, limited biodistribution, and inefficient uptake of nucleic acids. PEGylated liposomes show considerable promise because of their intrinsic ability to accumulate at disease sites and facilitate
Brett A Duguay et al.
Journal of leukocyte biology, 104(3), 587-596 (2018-04-19)
Mast cells are important immune cells that have significant roles in mediating allergy and asthma. Therefore, studying the molecular mechanisms regulating these and other processes in mast cells is important to elucidate. Methods such as lipofection, transduction, and electroporation are
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