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Merck
CN

55171

Sigma-Aldrich

(23R)-23,25-二羟基维生素 D3

≥99.0% (HPLC)

别名:

(23R)-23,25-Dihydroxycholecalciferol

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关于此项目

经验公式(希尔记法):
C27H44O3
化学文摘社编号:
分子量:
416.64
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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质量水平

方案

≥99.0% (HPLC)

表单

powder or crystals

颜色

colorless to white

运输

dry ice

储存温度

−20°C

SMILES字符串

C[C@H](C[C@@H](O)CC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O3/c1-18-8-11-22(28)16-21(18)10-9-20-7-6-14-27(5)24(12-13-25(20)27)19(2)15-23(29)17-26(3,4)30/h9-10,19,22-25,28-30H,1,6-8,11-17H2,2-5H3/b20-9+,21-10-/t19-,22+,23-,24-,25+,27-/m1/s1

InChI key

JVBPQHSRTHJMLM-WORHRCAZSA-N

应用

able to increase the plasma lactone concentration

生化/生理作用

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 23,25-Dihydroxyvitamin D3 is synthesized by the human placenta and by kidney cortex mitochondria.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Metabolic pathway to 25-hydroxyvitamin D3-26,23-lactone from 25-hydroxyvitamin D3.
S Ishizuka et al.
FEBS letters, 138(1), 83-87 (1982-02-08)
L Cancela et al.
Journal of steroid biochemistry, 28(5), 479-484 (1987-11-01)
Mouse skin fibroblasts in culture were used to study the regulation of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) induced 24 hydroxylase (24-OH-ase) under the influence of 3 agents: (1) 24,25-Dihydroxycholecalciferol (24,25(OH)2D3), 62.5 10(-9) M, which led to a significant decrease in the 1,25(OH)2D3-induced 24-OH-ase
J I Pedersen et al.
The Biochemical journal, 250(2), 527-532 (1988-03-01)
Incubation of 25-hydroxyvitamin D3 with kidney cortex mitochondria from 1,25-dihydroxyvitamin D3-treated guinea pigs resulted in the formation of 23,25-dihydroxyvitamin D3 as the major product. The identity of the product was verified by g.c.-m.s. and quantification was performed by h.p.l.c. The
T F Vlasova et al.
Voprosy pitaniia, (1)(1), 55-59 (1986-01-01)
Some aspects of amino acid metabolism in rats exposed to 30 days of hypokinesia were explored. The animals were placed on the diets with varying Ca/P ratio, containing 24, 25-dihydroxycholecalciferol (24, 25 (OH)2)D3, an active vitamin D3 metabolite. It was
Y Tanaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(8), 4805-4808 (1981-08-01)
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone

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