61229
硬脂酰-L-肉碱
≥97.0% (TLC)
别名:
(2R)-3-羧基-N,N,N-三甲基-2-[(1-氧代十八烷基)氧基]-1-丙烯胺 内盐, L-肉碱十八烷酸酯, C18-肉碱, 十八烷酰基-L-肉碱
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关于此项目
经验公式（希尔记法）:
C25H49NO4
化学文摘社编号:
分子量:
427.66
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
7309670
SMILES string
C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCCCC)=O)CC([O-])=O
InChI key
FNPHNLNTJNMAEE-HSZRJFAPSA-N
InChI
1S/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3/t23-/m1/s1
assay
≥97.0% (TLC)
optical activity
[α]/D -15±2°, c = 1 in methanol
impurities
≤10% water
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
在肉碱棕榈酰转移酶II缺乏的患者中发现的硬脂酰肉碱含量显著更高。肉碱棕榈酰转移酶，可通过与酰基辅酶A合成酶和肉碱/酰基肉碱转位酶结合，为长链脂肪酸从胞质溶胶转移到线粒体基质中进行β氧化提供了相关机理。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Global profiling of the muscle metabolome: method optimization, validation and application to determine exercise-induced metabolic effects.
Alves, R.D.A.M, et al.
Metabolomics, 11, 271-285 (2015)
Jie An et al.
Nature medicine, 10(3), 268-274 (2004-02-11)
Lipid infusion or ingestion of a high-fat diet results in insulin resistance, but the mechanism underlying this phenomenon remains unclear. Here we show that, in rats fed a high-fat diet, whole-animal, muscle and liver insulin resistance is ameliorated following hepatic
Yosuke Shigematsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 792(1), 63-72 (2003-06-28)
In a selective screening for fatty acid oxidation disorders by tandem mass spectrometry, we tested the diagnostic ratios and acylcarnitine concentrations in sera or blood spots, which were reported to be specific to very long-chain acyl CoA dehydrogenase deficiency, carnitine
Elizabeth C Randall et al.
Cancer research, 80(6), 1258-1267 (2019-11-27)
Glioblastoma (GBM) is increasingly recognized as a disease involving dysfunctional cellular metabolism. GBMs are known to be complex heterogeneous systems containing multiple distinct cell populations and are supported by an aberrant network of blood vessels. A better understanding of GBM
M Möder et al.
Analytical and bioanalytical chemistry, 375(2), 200-210 (2003-02-01)
l-Carnitine and its esters are products of intermediary metabolism of organisms. The distribution pattern or the favored excretion of individual acylcarnitines tells something about metabolic diseases. The determination of the urinary acylcarnitine pattern by flow injection analysis (FIA)-electrospray ionization (ESI)-mass
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