61350
TS-Link™ Bimane thiosulfate 钠盐
≥98.0% (HPCE)
别名:
Thiosulfuric acid S-{2-oxo-2-{[(2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazol-3-yl)methyl]amino}ethyl}ester 单钠盐
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关于此项目
经验公式（希尔记法）:
C12H14N3NaO6S2
化学文摘社编号:
分子量:
383.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
方案
≥98.0% (HPCE)
荧光
λex 386 nm; λem 480 nm in 0.1 M phosphate pH 7.0
适用性
corresponds for coupling to thiols
储存温度
−20°C
SMILES字符串
[Na+].CC1=C(C)C(=O)N2N1C(CNC(=O)CSS([O-])(=O)=O)=C(C)C2=O
InChI
1S/C12H15N3O6S2.Na/c1-6-8(3)14-9(7(2)12(18)15(14)11(6)17)4-13-10(16)5-22-23(19,20)21;/h4-5H2,1-3H3,(H,13,16)(H,19,20,21);/q;+1/p-1
InChI key
CFJHROSVZGHNCG-UHFFFAOYSA-M
应用
TS-Link Bimane thiosulfate sodium salt is used to fluorescence label sulfhydryls found in proteins and other biomolecules such as glutathione. In contrast to the thioether bonds formed by maleimides and iodoacetamides, the disulfide bonds formed by TS-Link reagents are reversible — the TS-Link hapten or fluorophore can easily be removed using a reducing agent such as DTT or TCEP. TS-Link reagents are selective for thiols at neutral pH, whereas maleimides will react with other functional groups. TS-Link Bimane thiosulfate sodium salt may be used in comparison with other sulfhydryl coupling strategies.
法律信息
TS-Link is a trademark of Life Technologies
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Dilip Shrestha et al.
Analytical and bioanalytical chemistry, 404(5), 1449-1463 (2012-07-17)
The progression in bioconjugational chemistry has significantly contributed to the evolution and success of protein biology. Mainly, antibody chemistry has been a subject of intensive study owing to the expansion of research areas warranted by using various derivatives of conjugated
R C Fahey et al.
Journal of molecular evolution, 25, 81-88 (1987-01-01)
Of the many roles ascribed to glutathione (GSH) the one most clearly established is its role in the protection of higher eucaryotes against oxygen toxicity through destruction of thiol-reactive oxygen byproducts. If this is the primary function of GSH then
Abhijit Ray et al.
Bioorganic & medicinal chemistry letters, 16(6), 1473-1476 (2006-01-03)
The purpose of this study was to design bile acid-containing methanethiosulfonate (MTS) agents with appropriate physical attributes to effectively modify the cysteine residues present in the human apical sodium-dependent bile acid transporter. Four physical properties including surface area, molecular volume
Gary D Pipes et al.
Pharmaceutical research, 22(7), 1059-1068 (2005-07-20)
The aim of the study is to provide a methodology for assigning unpaired cysteine residues in proteins formulated in a variety of different conditions to identify structural heterogeneity as a potential cause for protein degradation. 1-Cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) was employed
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