67376
Sodium (R)-homocitrate tribasic
≥90.0%
别名:
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid trisodium salt, (R)-Homocitrate trisodium salt
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关于此项目
经验公式（希尔记法）:
C7H7Na3O7
化学文摘社编号:
分子量:
272.10
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
方案
≥90.0%
旋光性
[α]/D -11.0±2.0°, c = 0.1 in H2O
杂质
≤15.0% water
SMILES字符串
[Na+].[Na+].[Na+].O[C@](CCC([O-])=O)(CC([O-])=O)C([O-])=O
InChI
1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3/t7-;;;/m1.../s1
InChI key
SNTBDRNHMPWDFS-LSBIWMFESA-K
应用
(R)-Homocitrate trisodium salt may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.
生化/生理作用
Important metabolite of lysine biosynthesis, pyruvate and 2-oxocarboxylic acid metabolism, homocitrate is as a sensor of lysine-pathway distress, it has a dynamic role during nitrogen fixation.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Eye Irrit. 2
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Yilin Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17125-17130 (2006-10-26)
The Fe protein is indispensable for nitrogenase catalysis and biosynthesis. However, its function in iron-molybdenum cofactor (FeMoco) biosynthesis has not been clearly defined. Here we show that the Fe protein can act as a Mo/homocitrate insertase that mobilizes Mo/homocitrate for
Marcus C Durrant et al.
The Biochemical journal, 397(2), 261-270 (2006-03-29)
Although it is generally accepted that the active site of nitrogenase is located on the FeMo-cofactor, the exact site(s) of N2 binding and reduction remain the subject of continuing debate, with both molybdenum and iron atoms being suggested as key
L Ma et al.
The Journal of biological chemistry, 269(27), 18007-18015 (1994-07-08)
Here we report the large scale isolation and characterization of a species, designated MoFe cluster, that exhibits an S = 3/2 EPR signal, and the comparison of this entity to isolated FeMo cofactor in N-methylformamide and to the active site
J Imperial et al.
Biochemistry, 28(19), 7796-7799 (1989-09-19)
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid [(R)-homocitrate] has been has been recently reported to be an integral constituent of the otherwise thought to be inorganic iron-molybdenum cofactor of dinitrogenase [Hoover, T.R., Imperial, J., Ludden, P.W., & Shah, V.K. (1989) Biochemistry 28,2768-2771]. Different organic acids
Leonardo Curatti et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17626-17631 (2007-11-06)
Biological nitrogen fixation, the conversion of atmospheric N2 to NH3, is an essential process in the global biogeochemical cycle of nitrogen that supports life on Earth. Most of the biological nitrogen fixation is catalyzed by the molybdenum nitrogenase, which contains
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