67376
Sodium (R)-homocitrate tribasic
≥90.0%
别名:
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid trisodium salt, (R)-Homocitrate trisodium salt
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关于此项目
经验公式（希尔记法）:
C7H7Na3O7
化学文摘社编号:
分子量:
272.10
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
SNTBDRNHMPWDFS-LSBIWMFESA-K
SMILES string
[Na+].[Na+].[Na+].O[C@](CCC([O-])=O)(CC([O-])=O)C([O-])=O
InChI
1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3/t7-;;;/m1.../s1
assay
≥90.0%
optical activity
[α]/D -11.0±2.0°, c = 0.1 in H2O
impurities
≤15.0% water
Application
(R)-Homocitrate trisodium salt may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.
Biochem/physiol Actions
Important metabolite of lysine biosynthesis, pyruvate and 2-oxocarboxylic acid metabolism, homocitrate is as a sensor of lysine-pathway distress, it has a dynamic role during nitrogen fixation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Yilin Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17125-17130 (2006-10-26)
The Fe protein is indispensable for nitrogenase catalysis and biosynthesis. However, its function in iron-molybdenum cofactor (FeMoco) biosynthesis has not been clearly defined. Here we show that the Fe protein can act as a Mo/homocitrate insertase that mobilizes Mo/homocitrate for
Marcus C Durrant et al.
The Biochemical journal, 397(2), 261-270 (2006-03-29)
Although it is generally accepted that the active site of nitrogenase is located on the FeMo-cofactor, the exact site(s) of N2 binding and reduction remain the subject of continuing debate, with both molybdenum and iron atoms being suggested as key
L Ma et al.
The Journal of biological chemistry, 269(27), 18007-18015 (1994-07-08)
Here we report the large scale isolation and characterization of a species, designated MoFe cluster, that exhibits an S = 3/2 EPR signal, and the comparison of this entity to isolated FeMo cofactor in N-methylformamide and to the active site
Franco Teves et al.
Microbiology (Reading, England), 155(Pt 12), 3881-3892 (2009-08-22)
The lysine biosynthetic pathway has to supply large amounts of alpha-aminoadipic acid for penicillin biosynthesis in Penicillium chrysogenum. In this study, we have characterized the P. chrysogenum L2 mutant, a lysine auxotroph that shows highly increased expression of several lysine
Leonardo Curatti et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17626-17631 (2007-11-06)
Biological nitrogen fixation, the conversion of atmospheric N2 to NH3, is an essential process in the global biogeochemical cycle of nitrogen that supports life on Earth. Most of the biological nitrogen fixation is catalyzed by the molybdenum nitrogenase, which contains
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