69591
4-甲基伞形酮 α- D -吡喃葡萄糖苷
≥98% (TLC)
别名:
4-甲基伞形酮 α- D -葡萄糖苷
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关于此项目
经验公式（希尔记法）:
C16H18O8
化学文摘社编号:
分子量:
338.31
UNSPSC Code:
12352204
NACRES:
NA.25
PubChem Substance ID:
EC Number:
241-794-0
Beilstein/REAXYS Number:
1690776
MDL number:
InChI
1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1
InChI key
YUDPTGPSBJVHCN-JZYAIQKZSA-N
SMILES string
CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12
Quality Level
assay
≥98% (TLC)
form
powder
solubility
DMSO: 50 mg/mL, clear, colorless to faintly yellow
fluorescence
λex 316 nm; λem 375 nm (Reaction product), λex 317 nm; λem 374 nm (pH9.0), λex 360 nm; λem 449 nm, λex 365 nm; λem 445 nm in 0.1 M Tris pH 8.0 (α-glucosidase)
storage temp.
−20°C
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General description
4-甲基伞形酮α-D-吡喃葡萄糖苷是 α -葡萄糖苷酶的荧光底物。 4-甲基伞形酮α-D-吡喃葡萄糖苷，又称 4MU- α-glc，反应后生成产物 4MU，其荧光光谱峰值为 440nm。
Application
4-甲基伞形酮α-D-吡喃葡萄糖苷可作为荧光底物，用于α-D-葡萄糖苷酶的鉴别、表征和动力学分析。4-甲基伞形酮α-D-吡喃葡萄糖苷用于高通量筛选实验。它适用于肾脏及白细胞的庞佩氏症诊断。
Packaging
无底玻璃瓶。内容物在插入的熔锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
D M Broadhead et al.
Clinical genetics, 13(6), 504-510 (1978-06-01)
The diagnosis of Pompe's disease by the assay of acid alpha-glucosidase in kidney and leucocytes was not previously possible because of the presence of another component which had activity at pH 4.0, but was not deficient in the disease. This
Blanca I Torres-Rodríguez et al.
Antonie van Leeuwenhoek, 101(2), 313-322 (2011-09-20)
The early steps of glycoprotein biosynthesis involve processing of the N-glycan core by endoplasmic reticulum α-glucosidases I and II which sequentially trim the outermost α1,2-linked and the two more internal α1,3-linked glucose units, respectively. We have demonstrated the presence of
A.Holzapfel-Pschorn et al.
Fresenius Journal of Analytical Chemistry, 327, 521-521 (1987)
Shohei Shigeto et al.
Molecular genetics and metabolism, 103(1), 12-17 (2011-02-16)
The high frequency (3.3-3.9%) of acid α-glucosidase pseudodeficiency, c.[1726G>A; 2065G>A] homozygote (AA homozygote), in Asian populations complicates newborn screening for Pompe disease (glycogen storage disease type II or acid maltase deficiency) on dried blood spots, since AA homozygotes have a
Lara W Katzin et al.
Journal of clinical neuromuscular disease, 9(4), 421-431 (2008-06-06)
Pompe disease, or glycogen storage disease type II, is a rare autosomal recessive disorder caused by mutations in the gene that encodes for alpha-glucosidase. Presentation in infancy is associated with respiratory failure, cardiomyopathy, and severe muscle weakness. Juvenile- or adult-onset
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