72335
9-(2,2-二氰乙烯基)久洛啶
BioReagent, suitable for fluorescence, ≥97.0% (HPLC)
别名:
9-久洛啶基亚甲基丙二腈, DCVJ
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关于此项目
经验公式（希尔记法）:
C16H15N3
化学文摘社编号:
分子量:
249.31
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
413882
产品名称
9-(2,2-二氰乙烯基)久洛啶, BioReagent, suitable for fluorescence, ≥97.0% (HPLC)
InChI key
LROAUBRDKLVBCP-UHFFFAOYSA-N
SMILES string
N#C\C(=C/c1cc2CCCN3CCCc(c1)c23)C#N
InChI
1S/C16H15N3/c17-10-13(11-18)7-12-8-14-3-1-5-19-6-2-4-15(9-12)16(14)19/h7-9H,1-6H2
product line
BioReagent
assay
≥97.0% (HPLC)
form
crystals
solubility
DMSO: soluble
chloroform: soluble
fluorescence
λex 433 nm; λem 500 nm in 50 mM Tris pH 8.0; 40% glycerol
suitability
suitable for fluorescence
Quality Level
Other Notes
作为荧光探针，用于结合蛋白质等，通过减少自由旋转来增加量子产率；吸收波长在~450nm处，发射波长在480-505nm处（溶剂dep.）
Packaging
无底玻璃瓶。内容物在插入式融锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence.
M A Haidekker et al.
American journal of physiology. Heart and circulatory physiology, 278(4), H1401-H1406 (2000-04-06)
Fluid shear stress (FSS) has been shown to be an ubiquitous stimulator of mammalian cell metabolism. Although many of the intracellular signal transduction pathways have been characterized, the primary mechanoreceptor for FSS remains unknown. One hypothesis is that the cytoplasmic
A Bhattacharyya et al.
Indian journal of biochemistry & biophysics, 32(6), 442-446 (1995-12-01)
Di(cyano vinyl)julolidine (DCVJ) is a fluorescent probe which has been used to monitor the local mobility of its binding sites on proteins. It shows a concentration dependence of its emission spectrum in water. At higher DCVJ concentrations, a longer wavelength
Andrea Hawe et al.
Pharmaceutical research, 27(2), 314-326 (2009-12-31)
The aim was to evaluate fluorescent molecular rotors (DCVJ and CCVJ), which are mainly sensitive to viscosity, for the characterization of polysorbate-containing IgG formulations and compare them to the polarity-sensitive dyes ANS, Bis-ANS and Nile Red. IgG formulations with polysorbate
A Bhattacharya et al.
Protein science : a publication of the Protein Society, 5(10), 2029-2036 (1996-10-01)
9-(Dicyanovinyl) julolidine (DCVJ) is a fluorescent probe, which binds to a unique site on the tubulin dimer and exhibits different properties that are dependent upon its oligomeric state (Kung & Reed, 1989). DCVJ binds to tubulin, the tubulin-colchicine complex, and
Dexter N Dean et al.
Biochemistry, 55(15), 2238-2250 (2016-03-26)
Oligomers of amyloid-β (Aβ) have emerged as the primary toxic agents responsible for early synaptic dysfunction and neuronal death in Alzheimer's disease (AD). Characterization of oligomers is an important step in the progress toward delineating the complex molecular mechanisms involved
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