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72335

9-(2,2-二氰乙烯基)久洛啶

Name: 9-(2,2-二氰乙烯基)久洛啶
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

别名:

9-久洛啶基亚甲基丙二腈, DCVJ

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₅N₃

化学文摘社编号:

58293-56-4

分子量:

249.31

UNSPSC Code:

12352108

NACRES:

NA.32

PubChem Substance ID:

57652412

MDL number:

MFCD01747392

Beilstein/REAXYS Number:

413882

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product line

BioReagent

Quality Level

100

assay

≥97.0% (HPLC)

form

crystals

solubility

DMSO: soluble, chloroform: soluble

fluorescence

λ_ex 433 nm; λ_em 500 nm in 50 mM Tris pH 8.0; 40% glycerol

suitability

suitable for fluorescence

SMILES string

N#C\C(=C/c1cc2CCCN3CCCc(c1)c23)C#N

InChI

1S/C16H15N3/c17-10-13(11-18)7-12-8-14-3-1-5-19-6-2-4-15(9-12)16(14)19/h7-9H,1-6H2

InChI key

LROAUBRDKLVBCP-UHFFFAOYSA-N

Packaging

无底玻璃瓶。内容物在插入式融锥内。

Other Notes

作为荧光探针，用于结合蛋白质等，通过减少自由旋转来增加量子产率；吸收波长在~450nm处，发射波长在480-505nm处（溶剂dep.）

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Flow-dependent fluorescence of CCVJ.

Markus J Schmidt et al.

Journal of biological engineering, 11, 24-24 (2017-08-09)

The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a previously reported photoisomeric behavior may contribute to the measured fluorescence intensity

Fluorescent molecular rotors: a new class of probes for tubulin structure and assembly.

C E Kung et al.

Biochemistry, 28(16), 6678-6686 (1989-08-08)

9-(Dicyanovinyl)julolidine (DCVJ) is a fluorescent dye whose intramolecular rotational relaxation is solvent dependent. Since its quantum yield increases with decreasing free volume, this molecule has been very useful in monitoring synthetic polymer reactions and measuring local microviscosity changes in phospholipid

A Flow-Cytometry-Based Approach to Facilitate Quantification, Size Estimation and Characterization of Sub-visible Particles in Protein Solutions.

Christian Lubich et al.

Pharmaceutical research, 32(9), 2863-2876 (2015-03-20)

Sub-visible particles were shown to facilitate unwanted immunogenicity of protein therapeutics. To understand the root cause of this phenomenon, a comprehensive analysis of these particles is required. We aimed at establishing a flow-cytometry-based technology to analyze the amount, size distribution

A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells.

T Furuno et al.

Immunology letters, 33(3), 285-288 (1992-08-01)

A confocal fluorescence microscope was used to study the exocytotic secretory processes of mast cells in combination with an fluorescent molecular rotor, 9-(dicyanovinyl)julolidine (DCVJ). DCVJ is known to be an unique fluorescent dye which increases its quantum yield with decreasing

9-(Dicyanovinyl)julolidine binding to bovine brain calmodulin.

T Iio et al.

Journal of biochemistry, 109(4), 499-502 (1991-04-01)

A molecular rotor, 9-(dicyanovinyl)julolidine (DCVJ), is a fluorescent dye whose intramolecular rotation determines its fluorescence yield [Kung, C.E. & Reed, J.K. (1989) Biochemistry 28, 6678-6686]. DCVJ binds to bovine brain calmodulin and emits strong fluorescence. In fluorescence titration experiments, the

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货号	GTIN
72335-5MG	04061834370659

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