74359
N-[（RS）-3-羟基丁酰基]-L-高丝氨酸内酯
≥96% (HPLC)
别名:
3-羟基-C4-HSL, N-（3-羟基丁酰基）-L-高丝氨酸内酯
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关于此项目
经验公式（希尔记法）:
C8H13NO4
化学文摘社编号:
分子量:
187.19
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C8H13NO4/c1-5(10)4-7(11)9-6-2-3-13-8(6)12/h5-6,10H,2-4H2,1H3,(H,9,11)/t5?,6-/m0/s1
SMILES string
CC(O)CC(=O)N[C@H]1CCOC1=O
InChI key
FIXDIFPJOFIIEC-GDVGLLTNSA-N
assay
≥96% (HPLC)
form
powder
storage temp.
−20°C
Biochem/physiol Actions
N-[（RS）-3-羟基丁酰基] -L-高丝氨酸内酯是 N-酰基-高丝氨酸内酯家族的成员。N-酰基高丝氨酸内酯（AHL）调节革兰氏阴性细菌（如埃希氏菌和沙门氏菌）中的基因表达，参与群体感应，细菌间的细胞间通讯；要查看综述，请见 。 细菌的细胞间通讯已成为新型抗毒力药物开发的靶标，也是预防生物膜形成的研究热点。
群体感应信号发生
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
B L Hanzelka et al.
Journal of bacteriology, 181(18), 5766-5770 (1999-09-11)
Acylhomoserine lactones, which serve as quorum-sensing signals in gram-negative bacteria, are produced by members of the LuxI family of synthases. LuxI is a Vibrio fischeri enzyme that catalyzes the synthesis of N-(3-oxohexanoyl)-L-homoserine lactone from an acyl-acyl carrier protein and S-adenosylmethionine.
Sathish Rajamani et al.
Journal of microbiological methods, 84(2), 189-193 (2010-12-07)
Many bacteria produce and secrete proteases during host invasion and pathogenesis. Vibrio harveyi, an opportunistic pathogen of shrimp, is known to use a two-component quorum sensing (QS) mechanism for coordination of gene expression including protease secretion at high population densities.
Clay Fuqua et al.
Nature reviews. Molecular cell biology, 3(9), 685-695 (2002-09-05)
Bacterial cell-to-cell signalling has emerged as a new area in microbiology. Individual bacterial cells communicate with each other and co-ordinate group activities. Although a lot of detail is known about the mechanisms of a few well-characterized bacterial communication systems, other
M B Miller et al.
Annual review of microbiology, 55, 165-199 (2001-09-07)
Quorum sensing is the regulation of gene expression in response to fluctuations in cell-population density. Quorum sensing bacteria produce and release chemical signal molecules called autoinducers that increase in concentration as a function of cell density. The detection of a
Bonnie L Bassler
Cell, 109(4), 421-424 (2002-06-28)
In a process called quorum sensing, groups of bacteria communicate with one another to coordinate their behavior and function like a multicellular organism. A diverse array of secreted chemical signal molecules and signal detection apparatuses facilitate highly productive intra- and
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