74359
N-[（RS）-3-羟基丁酰基]-L-高丝氨酸内酯
≥96% (HPLC)
别名:
3-羟基-C4-HSL, N-（3-羟基丁酰基）-L-高丝氨酸内酯
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C8H13NO4
化学文摘社编号:
分子量:
187.19
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C8H13NO4/c1-5(10)4-7(11)9-6-2-3-13-8(6)12/h5-6,10H,2-4H2,1H3,(H,9,11)/t5?,6-/m0/s1
SMILES string
CC(O)CC(=O)N[C@H]1CCOC1=O
InChI key
FIXDIFPJOFIIEC-GDVGLLTNSA-N
assay
≥96% (HPLC)
form
powder
storage temp.
−20°C
Biochem/physiol Actions
N-[（RS）-3-羟基丁酰基] -L-高丝氨酸内酯是 N-酰基-高丝氨酸内酯家族的成员。N-酰基高丝氨酸内酯（AHL）调节革兰氏阴性细菌（如埃希氏菌和沙门氏菌）中的基因表达，参与群体感应，细菌间的细胞间通讯；要查看综述，请见 。 细菌的细胞间通讯已成为新型抗毒力药物开发的靶标，也是预防生物膜形成的研究热点。
群体感应信号发生
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
B L Hanzelka et al.
Journal of bacteriology, 181(18), 5766-5770 (1999-09-11)
Acylhomoserine lactones, which serve as quorum-sensing signals in gram-negative bacteria, are produced by members of the LuxI family of synthases. LuxI is a Vibrio fischeri enzyme that catalyzes the synthesis of N-(3-oxohexanoyl)-L-homoserine lactone from an acyl-acyl carrier protein and S-adenosylmethionine.
Sathish Rajamani et al.
Journal of microbiological methods, 84(2), 189-193 (2010-12-07)
Many bacteria produce and secrete proteases during host invasion and pathogenesis. Vibrio harveyi, an opportunistic pathogen of shrimp, is known to use a two-component quorum sensing (QS) mechanism for coordination of gene expression including protease secretion at high population densities.
M R Parsek et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(8), 4360-4365 (1999-04-14)
Acyl homoserine lactones (acyl-HSLs) are important intercellular signaling molecules used by many bacteria to monitor their population density in quorum-sensing control of gene expression. These signals are synthesized by members of the LuxI family of proteins. To understand the mechanism
Margrith E Mattmann et al.
The Journal of organic chemistry, 75(20), 6737-6746 (2010-08-03)
Bacteria use small molecule signals to access their local population densities in a process called quorum sensing (QS). Once a threshold signal concentration is reached, and therefore a certain number of bacteria have assembled, bacteria use QS to change gene
Barbara Thallinger et al.
Biotechnology journal, 8(1), 97-109 (2013-01-03)
With the increasing prevalence of antibiotic resistance, antimicrobial enzymes aimed at the disruption of bacterial cellular machinery and biofilm formation are under intense investigation. Several enzyme-based products have already been commercialized for application in the healthcare, food and biomedical industries.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持