76904
维库溴铵
别名:
1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-piperidinium bromide
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关于此项目
经验公式（希尔记法）:
C34H57BrN2O4
CAS Number:
分子量:
637.73
Beilstein:
4837308
EC 号:
MDL编号:
UNSPSC代码:
51152000
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic
质量水平
方案
≥97.0% (TLC)
表单
powder or crystals
官能团
carboxylic acid
SMILES字符串
[Br-].CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@@H]([C@@H]4OC(C)=O)[N+]5(C)CCCCC5)[C@@]2(C)C[C@@H]1N6CCCCC6
InChI
1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
InChI key
VEPSYABRBFXYIB-PWXDFCLTSA-M
基因信息
human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)
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生化/生理作用
Vecuronium Bromide is an aminosteroidal neuromuscular blocking agent. It relaxes the skeletal muscle and decreases oxygen consumption during surgery. It competes with acetylcholine and bind to cholinergic receptors at neuromuscular junctions.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
Hong Wang et al.
Acta pharmacologica Sinica, 32(12), 1454-1459 (2011-10-12)
To investigate the effect of magnesium sulfate and its interaction with the non-depolarizing muscle relaxant vecuronium at adult muscle-type acetylcholine receptors in vitro. Adult muscle-type acetylcholine receptors were expressed in HEK293 cells. Drug-containing solution was applied via a gravity-driven perfusion
Hong WANG et al.
Acta pharmacologica Sinica, 31(12), 1541-1546 (2010-11-26)
to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated
Shawn P Vorce et al.
Journal of analytical toxicology, 32(6), 422-427 (2008-07-26)
The apparent recreational use of an aminosteroidal non-depolarizing neuromuscular blocking agent, vecuronium, is reported in this postmortem investigation. A quantitative method for the analysis of vecuronium and its active metabolite, 3-desacetylvecuronium, in blood and tissue samples was developed using liquid
K R Vega-Villa et al.
British journal of anaesthesia, 112(2), 304-310 (2013-09-27)
Burn patients develop resistance to non-depolarizing neuromuscular blocking agents (NDNMBAs) and require a significantly large dose to produce a desired clinical response. Pathophysiological changes related to burn injury may alter pharmacokinetics (PK) and pharmacodynamics of NDNMBAs. The purpose of this
K Nitahara et al.
Anaesthesia, 68(9), 904-907 (2013-06-25)
We investigated whether a bolus injection of 20 ml saline with arm elevation might shorten the onset time of vecuronium administered via a dorsal hand vein. Thirty patients were randomly allocated to the bolus saline group or control group. General
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