82934
7-Hydroxycitronellal
Odorant used in allergy studies
别名:
7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate
等级
Molecular Biology
质量水平
方案
≥95.0% (GC)
表单
powder
密度
0.92 g/mL at 20 °C (lit.)
储存温度
room temp
SMILES字符串
[H]C(CC(C)CCCC(O)(C)C)=O
InChI
1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3
InChI key
WPFVBOQKRVRMJB-UHFFFAOYSA-N
一般描述
7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.
应用
Suitable for
- contact sensitization studies to identify allergens present in cosmetic preparations
- elucidation of molecular pathways related to allergic reactions
- analytical standard
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
R A Ford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(11-12), 921-926 (1988-11-01)
Hydroxycitronellal, an important ingredient in fragrances, was studied for its sensitizing potential in human skin. Fifteen human maximization tests were conducted with hydroxycitronellal obtained from four different sources at induction concentrations from 5 to 12%. No reactions were induced at
Hydroxycitronellal: A survey of consumer patch-test sensitization.
R J Steltenkamp et al.
Food and cosmetics toxicology, 18(4), 407-412 (1980-08-01)
Facial psoriasis caused by contact allergy to linalool and hydroxycitronellal in an after-shave.
A C de Groot et al.
Contact dermatitis, 9(3), 230-232 (1983-05-01)
H Wahlkvist et al.
Contact dermatitis, 41(4), 198-206 (1999-10-09)
A multi-dose-response induction protocol for the guinea pig maximization test (GPMT), including a statistical computer program, has earlier been developed to improve the power of predictive tests for identification of contact allergens. This dose-response protocol, with 2 modifications (i.e., increased
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